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Nanocarriers for Combination Therapy in Pancreatic Ductal Adenocarcinoma: A Comprehensive Review
| dc.contributor | Universitat Ramon Llull. IQS | |
| dc.contributor.author | Pontón, Iris | |
| dc.contributor.author | Sánchez-García, David | |
| dc.date.accessioned | 2025-09-15T15:51:14Z | |
| dc.date.available | 2025-09-15T15:51:14Z | |
| dc.date.issued | 2025-08-01 | |
| dc.identifier.issn | 2079-4991 | ca |
| dc.identifier.uri | http://hdl.handle.net/20.500.14342/5511 | |
| dc.description.abstract | Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers worldwide, characterized by late diagnosis, aggressive progression, and poor response to conventional monotherapies. Combination therapies have emerged as a promising approach to overcome multidrug resistance (MDR), enhance efficacy, and target the complex tumor microenvironment (TME). Nanoparticle-based drug delivery systems (DDSs) have gained significant attention for their ability to co-deliver multiple agents with controlled release profiles. This review comprehensively examines nanoparticle-based platforms developed for PDAC combination therapies, focusing on small-molecule drugs. The systems discussed are drawn from studies published between 2005 and 2025. | ca |
| dc.format.extent | p.26 | ca |
| dc.language.iso | eng | ca |
| dc.publisher | MDPI | ca |
| dc.relation.ispartof | Nanomaterials 2025, 15 (15), 1139 | ca |
| dc.rights | © L'autor/a | ca |
| dc.rights | Attribution 4.0 International | ca |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.other | Pancreatic cancer | ca |
| dc.subject.other | Pancreatic ductal adenocarcinoma | ca |
| dc.subject.other | Nanoparticles | ca |
| dc.subject.other | Nanomedicine | ca |
| dc.subject.other | Combination therapy | ca |
| dc.subject.other | Multi-drug resistance | ca |
| dc.subject.other | Chemotherapy | ca |
| dc.subject.other | Stromal therapy | ca |
| dc.subject.other | Pàncrees--Càncer | ca |
| dc.subject.other | Nanopartícules | ca |
| dc.subject.other | Nanomedicina | ca |
| dc.subject.other | Terapia combinada | ca |
| dc.subject.other | Resistència als medicaments | ca |
| dc.subject.other | Quimioteràpia | ca |
| dc.title | Nanocarriers for Combination Therapy in Pancreatic Ductal Adenocarcinoma: A Comprehensive Review | ca |
| dc.type | info:eu-repo/semantics/article | ca |
| dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
| dc.embargo.terms | cap | ca |
| dc.subject.udc | 577 | ca |
| dc.identifier.doi | https://doi.org/10.3390/nano15151139 | ca |
| dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
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