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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorBedrossiantz, Juliette
dc.contributor.authorGoyenechea, Júlia
dc.contributor.authorPrats, Eva
dc.contributor.authorGómez Canela, Cristian
dc.contributor.authorBarata, Carlos
dc.contributor.authorRaldúa, Demetrio
dc.contributor.authorCachot, Jérôme
dc.date.accessioned2025-01-09T19:43:38Z
dc.date.available2025-01-09T19:43:38Z
dc.date.issued2024-03-16
dc.identifier.issn1873-6424ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/4712
dc.description.abstractBoscalid (2-Chloro-N-(4′-chlorobiphenyl-2-yl) nicotinamide), a pyridine carboxamide fungicide, is an inhibitor of the complex II of the respiration chain in fungal mitochondria. As boscalid is only moderately toxic for aquatic organisms (LC50 > 1–10 mg/L), current environmental levels of this compound in aquatic ecosystems, in the range of ng/L-μg/L, are considered safe for aquatic organisms. In this study, we have exposed zebrafish (Danio rerio), Japanese medaka (Oryzias latipes) and Daphnia magna to a range of concentrations of boscalid (1–1000 μg/L) for 24 h, and the effects on heart rate (HR), basal locomotor activity (BLA), visual motor response (VMR), startle response (SR), and habituation (HB) to a series of vibrational or light stimuli have been evaluated. Moreover, changes in the profile of the main neurotransmitters have been determined. Boscalid altered HR in a concentration-dependent manner, leading to a positive or negative chronotropic effect in fish and D. magna, respectively. While boscalid decreased BLA and increased VMR in Daphnia, these behaviors were not altered in fish. For SR and HB, the response was more species- and concentration-specific, with Daphnia exhibiting the highest sensitivity. At the neurotransmission level, boscalid exposure decreased the levels of L-aspartic acid in fish larvae and increased the levels of dopaminergic metabolites in D. magna. Our study demonstrates that exposure to environmental levels of boscalid alters cardiac activity, impairs ecologically relevant behaviors, and leads to changes in different neurotransmitter systems in phylogenetically distinct vertebrate and invertebrate models. Thus, the results presented emphasize the need to review the current regulation of this fungicide.ca
dc.format.extent12 p.ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofEnvironmental Pollution. 2024;347:123685ca
dc.rights© L'autor/aca
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.otherFungicideca
dc.subject.otherSuccinate dehydrogenase inhibitorca
dc.subject.otherAquatic organismsca
dc.subject.otherEnvironmental toxicologyca
dc.subject.otherHeart rateca
dc.subject.otherBehaviorca
dc.titleCardiac and neurobehavioral impairments in three phylogenetically distant aquatic model organisms exposed to environmentally relevant concentrations of boscalidca
dc.typeinfo:eu-repo/semantics/annotationca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc5ca
dc.identifier.doihttps://doi.org/10.1016/j.envpol.2024.123685ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI-MCIN/PN I+D/PID2020-113371RB-C21ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI-MCIN/PN I+D/PID2020-113371RB-C22ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR_902ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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