The Retro-Aza-Michael Reaction: How Process Optimization Led to New Scientific Insights
Other authors
Publication date
2024ISSN
0001-9704
Abstract
The synthesis of 2-(2-methylaminoethyl)pyridine from the reaction between 2-vinylpyridine and methylamine serves as a crucial exploration into the reversibility of the aza-Michael reaction. The results unequivocally demonstrate the notable reversibility inherent in the aza-Michael reaction. This characteristic assumes a pivotal role in fostering heightened selectivity, particularly in the realm of Flow Chemistry, where operating temperatures surpass the typical boiling points of the involved mixtures. A preliminary kinetic model, grounded in first-order reactions, aligns well with the experimental data. Results from microwave and Flow Chemistry allow for an initial approximation of the parameters governing the observed equilibrium, providing a foundational understanding of the reaction dynamics. This insight into the reversibility and kinetic aspects of the aza-Michael reaction contributes to the optimization of conditions for enhanced control and efficiency in synthetic processes, particularly under the unique conditions presented by Flow Chemistry.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
543 - Analytical chemistry
Keywords
Microwave Reactors
Flow Chemistry
Optimization
Reversibility
Selectivity
Pages
6 p.
Publisher
AIQS
Is part of
Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry, 2024;81(601):68-73
This item appears in the following Collection(s)
Rights
© L'autor/a
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/