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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorLazaro Carrillo, Ana
dc.contributor.authorRodríguez Amigo, Beatriz
dc.contributor.authorMora, Margarita
dc.contributor.authorSagristá, M. Lluïsa
dc.contributor.authorCañete, Magdalena
dc.contributor.authorNonell, Santi
dc.contributor.authorVillanueva, Angeles
dc.date.accessioned2024-10-25T06:28:31Z
dc.date.available2024-10-25T06:28:31Z
dc.date.issued2022
dc.identifier.issn1422-0067ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/4458
dc.description.abstractThe enhancement of photodynamic therapy (PDT) effectiveness by combining it with other treatment modalities and improved drug delivery has become an interesting field in cancer research. We have prepared and characterized nanoliposomes containing the chemotherapeutic drug irinotecan (CPT11lip), the photodynamic agent protoporphyrin IX (PpIXlip), or their combination (CPT11-PpIXlip). The effects of individual and bimodal (chemo-phototherapeutic) treatments on HeLa cells have been studied by a combination of biological and photophysical studies. Bimodal treatments show synergistic cytotoxic effects on HeLa cells at relatively low doses of PpIX/PDT and CPT11. Mechanistic cell inactivation studies revealed mitotic catastrophe, apoptosis, and senescence contributions. The enhanced anticancer activity is due to a sustained generation of reactive oxygen species, which increases the number of double-strand DNA breaks. Bimodal chemo-phototherapeutic liposomes may have a very promising future in oncological therapy, potentially allowing a reduction in the CPT11 concentration required to achieve a therapeutic effect and overcoming resistance to individual cancer treatments.ca
dc.format.extentp.19ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofInternational Journal of Molecular Sciences, 23(21), 2022, 12817ca
dc.rights© L'autor/aca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherPhotodynamic therapyca
dc.subject.otherProtoporphyrin IXca
dc.subject.otherIrinotecanca
dc.subject.otherChemo-phototherapyca
dc.subject.otherBimodalfunctionalized nanoliposomesca
dc.subject.otherSynergistic effectca
dc.subject.otherTime-lapse microscopyca
dc.subject.otherReactive oxygen speciesca
dc.subject.otherDouble-strand DNA breakca
dc.subject.otherSubcellular locationca
dc.titleDual-Functionalized Nanoliposomes Achieve a Synergistic Chemo-Phototherapeutic Effectca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc54ca
dc.subject.udc577ca
dc.identifier.doihttps://doi.org/10.3390/ijms232112817ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-2-Rca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICIN/PN I+D/PID2020-115801RB-C22ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/UAM/Teaching Assistant contract/20140513-136ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Severo Ochoa Excellence Accreditation/SEV-2016-0686ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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