Mostra el registre parcial de l'element

dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorRiera, Roger
dc.contributor.authorTauler, Jana
dc.contributor.authorFeiner Gracia, Natàlia
dc.contributor.authorBorrós i Gómez, Salvador
dc.contributor.authorFornaguera Puigvert, Cristina
dc.contributor.authorAlbertazzi, Lorenzo
dc.date.accessioned2024-10-22T12:25:09Z
dc.date.available2024-10-22T12:25:09Z
dc.date.issued2022
dc.identifier.issn1860-7187ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/4453
dc.description.abstractNanomedicine emerged some decades ago with the hope to be the solution for most unmet medical needs. However, tracking materials at nanoscale is challenging to their reduced size, below the resolution limit of most conventional techniques. In this context, we propose the use of direct stochastic optical reconstruction microscopy (dSTORM) to study time stability and cell trafficking after transfection of oligopeptide end-modified poly(β-aminoester) (OM-pBAE) nanoparticles. We selected different combinations of cationic end oligopeptides (arginine – R; histidine – H; and lysine – K) among polymer libraries, since the oligopeptide combination demonstrated to be useful for different applications, such as vaccination and gene silencing. We demonstrate that their time evolution as well as their cell uptake and trafficking are dependent on the oligopeptide. This study opens the pave to broad mechanistic studies at nanoscale that could enable a rational selection of specific pBAE nanoparticles composition after determining their stability and cell trafficking.ca
dc.format.extentp.8ca
dc.language.isoengca
dc.publisherWileyca
dc.relation.ispartofChemMedChem 2022, 17(13), e202100633ca
dc.rights© L'autor/aca
dc.rightsAttribution-NonCommercial 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.otherDirect stochastic optical reconstruction microscopy(dSTORM)ca
dc.subject.otherNanoparticlestabilityca
dc.subject.otherCell traffickingca
dc.subject.otherNanoparticlesca
dc.subject.otherNanopartículesca
dc.subject.otherCèl·lulesca
dc.titleComplex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopyca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc539ca
dc.subject.udc576ca
dc.identifier.doihttps://doi.org/10.1002/cmdc.202100633ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


Fitxers en aquest element

 

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

© L'autor/a
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by-nc/4.0/
Comparteix a TwitterComparteix a LinkedinComparteix a FacebookComparteix a TelegramComparteix a WhatsappImprimeix