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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorTexidó, Robert
dc.contributor.authorCabanach, Pol
dc.contributor.authorKaplan, Richard
dc.contributor.authorGarcía Bonillo, Cristina
dc.contributor.authorPérez, Darío
dc.contributor.authorZhang, Shuo
dc.contributor.authorBorrós i Gómez, Salvador
dc.contributor.authorPena-Francesch, Abdon
dc.date.accessioned2024-10-18T18:18:37Z
dc.date.available2024-10-18T18:18:37Z
dc.date.issued2022
dc.identifier.issn2196-7350ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/4440
dc.description.abstractDespite modern advancements in sterilization and medical practices, bacterial infections remain a significant concern in the implantation of medical devices. There is currently an urgent need for long-lasting and high-stable strategies to avoid the adhesion of bacteria to the wide range of materials present in medical devices. Here, a versatile methodology to create anti-biofouling coatings that prevent the adhesion of bacteria to silicone-based materials used in healthcare is reported. These coatings consist of bifunctional ethylene glycol dimethacrylate as an anchor between a zwitterionic polymer (SBMA), which provides antifouling properties, and a polydopamine layer that operates as an interfacial binder, providing mechanical strength and strong adhesion to elastomeric substrates. The coatings exhibit superhydrophilic and anti-biofouling properties, creating a strong “bacteriophobic effect” that leads to a >99% reduction in bacterial adhesion. This bacteriophobic coating is successfully implemented and validated in a commercial urinary catheter, reducing bacterial adhesion by 1–2 orders of magnitude and avoiding bacterial colonization to prevent catheter-associated urinary tract infections. The results presented here demonstrate the versatility, durability, and scalability of the coating methodology for preventing bacterial adhesion in silicone elastomers, which can be easily applied to other elastomeric materials used in medical devices beyond urinary tract infection prevention.ca
dc.format.extentp.8ca
dc.language.isoengca
dc.publisherWileyca
dc.relation.ispartofAdvanced Materials Interfaces, 2022, 9(30), 2201152ca
dc.rights© L'autor/aca
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherAntibiofoulingca
dc.subject.otherBacteriophobic coatingsca
dc.subject.otherBiopolymersca
dc.subject.otherMedical deviceca
dc.subject.otherMedical elastomerca
dc.subject.otherUrinary catheterca
dc.subject.otherZwitterionic polymerca
dc.subject.otherBiopolímersca
dc.titleBacteriophobic Zwitterionic/Dopamine Coatings for Medical Elastomersca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc54ca
dc.subject.udc620ca
dc.identifier.doihttps://doi.org/10.1002/admi.202201152ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/SGR 2017 1559ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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