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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorGonzález-Ríos, Nil
dc.contributor.authorArtigues Cladera, Margalida
dc.contributor.authorGuerra Rebollo, Marta
dc.contributor.authorPlanas, Antoni (Planas Sauter)
dc.contributor.authorBorrós i Gómez, Salvador
dc.contributor.authorFaijes, Magda
dc.contributor.authorFornaguera Puigvert, Cristina
dc.date.accessioned2024-06-20T18:34:17Z
dc.date.available2024-06-20T18:34:17Z
dc.date.issued2023-06-14
dc.identifier.issn2050-750Xca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/4123
dc.description.abstractmRNA vaccination has emerged as a prominent therapy for the future of medicine. Despite the colossal advance in this technology and worldwide efficacy proof (ca. COVID vaccines), mRNA carriers still lack cell/tissue specificity, leading to possible side effects, and reduced efficacy among others. Herein we make use of the ubiquitous affinity of antigen-presenting cells (APC)s for glycosides to achieve specific targeting. To achieve this goal, we designed a new generation of α-mannosyl functionalized oligopeptide-terminated poly(β-aminoester). Fine formulation of these polymers with mRNA resulted in nanoparticles decorated with surface-exposed α-mannoses with sizes around 180 nm and positive surface charge. Notably, these particles maintained their properties after freeze-drying and subsequent redispersion. Finally, our mRNA carriers preferentially targeted and transfected APCs in vitro and in vivo. In conclusion, we demonstrated, at a preclinical level, that the mannose functionalization enables more selective targeting of APCs and, thus, these polymer and nanoparticles are candidates for a new generation of mRNA immunotherapy vaccines.ca
dc.format.extent16 p.ca
dc.language.isoengca
dc.publisherRSCca
dc.relation.ispartofJournal of Materials Chemistry Bca
dc.rights© The Royal Society of Chemistry*
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.otherRNAca
dc.subject.otherVacunacióca
dc.subject.otherADN-polimerasesca
dc.titleNovel α-mannose-functionalized poly(β-amino ester) nanoparticles as mRNA vaccines with increased antigen presenting cell selectivity in the spleenca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc614ca
dc.identifier.doihttps://pubs.rsc.org/en/content/articlelanding/2023/tb/d3tb00607gca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2022 SGR 00537ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2022 SGR 00535ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN i AEI/PN I+D/PID2019-104350RB-I00ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN i AEI/PN I+D/PID2021-125910OB-I00ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN i AEI/PN I+D/10.13039/501100011033ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/AC22/00042ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/FCAECC/TRNSC213882FORNca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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© The Royal Society of Chemistry
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by-nc/4.0/
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