Mostra el registre parcial de l'element

dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorTroelstra, Marian Amber
dc.contributor.authorRunge, Jurgen Henk
dc.contributor.authorBurnhope, Emma
dc.contributor.authorPolcaro, Alessandro
dc.contributor.authorGuenthner, Christian
dc.contributor.authorSchneider, Torben
dc.contributor.authorRazavi, Reza
dc.contributor.authorIsmail, Tevfik F.
dc.contributor.authorMartorell López, Jordi
dc.contributor.authorSinkus, Ralph
dc.date.accessioned2024-06-10T20:13:04Z
dc.date.available2024-06-10T20:13:04Z
dc.date.issued2021-01-14
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/4099
dc.description.abstractChanges in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance elastography (MRE) approach for quantifying myocardial biomechanics using aortic valve closure-induced shear waves. Using motion-sensitized two-dimensional pencil beams, septal shear waves were imaged at high temporal resolution. Shear wave speed was measured using time-of-flight of waves travelling between two pencil beams and corrected for geometrical biases. After validation in phantoms, results from twelve healthy volunteers and five cardiac patients (two left ventricular hypertrophy, two myocardial infarcts, and one without confirmed pathology) were obtained. Torsional shear wave speed in the phantom was 3.0 ± 0.1 m/s, corresponding with reference speeds of 2.8 ± 0.1 m/s. Geometrically-biased flexural shear wave speed was 1.9 ± 0.1 m/s, corresponding with simulation values of 2.0 m/s. Corrected septal shear wave speeds were significantly higher in patients than healthy volunteers [14.1 (11.0–15.8) m/s versus 3.6 (2.7–4.3) m/s, p = 0.001]. The interobserver 95%-limits-of-agreement in healthy volunteers were ± 1.3 m/s and interstudy 95%-limits-of-agreement − 0.7 to 1.2 m/s. In conclusion, myocardial shear wave speed can be measured using aortic valve closure-induced shear waves, with cardiac patients showing significantly higher shear wave speeds than healthy volunteers. This non-invasive measure may provide valuable insights into the pathophysiology of heart failure.ca
dc.format.extent14 p.ca
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.ispartofScientific Reportsca
dc.rights© L'autor/a*
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherMiocarditisca
dc.subject.otherRessonància magnèticaca
dc.subject.otherImatgeria per ressonància magnèticaca
dc.subject.otherCardiologiaca
dc.subject.otherSistema cardiovascular--Malaltiesca
dc.subject.otherTranslational researchca
dc.titleShear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocityca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc616.1ca
dc.identifier.doihttps://doi.org/10.1038/s41598-020-79231-zca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/Grant No 668039ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EPSRC/EP/N011554/1ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/British Council/Newton Fund Institutional Links/172707526ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EPSRC i NIHR/WT 203148/Z/16/Zca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


Fitxers en aquest element

 

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

© L'autor/a
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by/4.0/
Comparteix a TwitterComparteix a LinkedinComparteix a FacebookComparteix a TelegramComparteix a WhatsappImprimeix