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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorBellot, Marina
dc.contributor.authorFaria, Melissa
dc.contributor.authorGómez Canela, Cristian
dc.contributor.authorRaldúa, Demetrio
dc.contributor.authorBarata, Carlos
dc.date.accessioned2024-05-14T18:41:06Z
dc.date.available2024-05-14T18:41:06Z
dc.date.issued2021-08-09
dc.identifier.issn2305-6304ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/4073
dc.description.abstractThis study assessed the effects of the monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms of action of deprenyl were also determined by studying the relationship between behaviour, MAO activity and neurotransmitter levels. Modulation of the D. magna monoamine system was accomplished by 24 h exposure to two model psychotropic pharmaceuticals with antagonistic and agonistic serotonin signalling properties: 10 mg/L of 4-chloro-DL-phenylalanine (PCPA) and 1 mg/L of deprenyl, respectively. Contrasting behavioural outcomes were observed for deprenyl and PCPA reflected in decreased basal locomotor activity and enhanced habituation for the former compound and delayed habituation for the latter one. Deprenyl exposure inhibited monoamine oxidase (MAO) activity and increased the concentrations of serotonin, dopamine and the dopamine metabolite 3-methoxytyramine in whole D. magna extracts. Our findings indicate that D. magna is a sensitive and useful nonvertebrate model for assessing the effects of short-term exposure to chemicals that alter monoamine signalling changes.ca
dc.format.extent10 p.ca
dc.language.isoengca
dc.publisherMDPIca
dc.relationSupplementary Materialsca
dc.relation.ispartofToxicsca
dc.relation.urihttps://www.mdpi.com/article/10.3390/toxics9080187/s1ca
dc.rights© L'autor/aca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherDaphnia magnaca
dc.subject.otherDeprenylca
dc.subject.otherNeurotransmissorsca
dc.subject.otherModulationca
dc.subject.otherPharmaceuticalsca
dc.titlePharmacological modulation of behaviour, serotonin and dopamine levels in daphnia magna exposed to the monoamine oxidase inhibitor deprenylca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc615ca
dc.identifier.doihttps://dx.doi.org/10.3390/toxics9080187ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI-MCI/PN I+D/PID2020-113371RB-C21ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/IDAEA-CSIC/CEX2018-000794-Sca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/2017-SGR-902ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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