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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorLucchi, Roberta
dc.contributor.authorBentanachs, Jordi
dc.contributor.authorOller Salvia, Benjamí
dc.date.accessioned2024-01-15T17:57:55Z
dc.date.available2024-01-15T17:57:55Z
dc.date.issued2021-04-26
dc.identifier.issn2374-7951ca
dc.identifier.urihttp://hdl.handle.net/20.500.14342/3723
dc.description.abstractThe high selectivity and affinity of antibody binding havemade antibodies all-pervasive tools in therapy, diagnosis, and basic science.A plethora of chemogenetic approaches has been devised to makeantibodies responsive to stimuli ranging from light to enzymatic activity,temperature, pH, ions, and effector molecules. Within a single decade, thefield of activatable antibodies has yielded marketed therapeutics capable ofengaging antigens that could not be targeted with traditional antibodies, aswell as new tools to control intracellular protein location and investigatebiological processes. Many opportunities remain untapped, waiting formore efficient and generally applicable masking strategies to be developedat the interface between chemistry and biotechnologyca
dc.format.extent15 p.ca
dc.language.isoengca
dc.publisherAmerican Chemical Societyca
dc.relation.ispartofACS Central Scienceca
dc.rights© L'autor/aca
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.otherAntigensca
dc.subject.otherBiopolymersca
dc.subject.otherCancer therapyca
dc.subject.otherImmunologyca
dc.subject.otherPeptides and proteinsca
dc.subject.otherAntígensca
dc.subject.otherBiopolímersca
dc.subject.otherCàncer--Tractamentca
dc.subject.otherImmunologiaca
dc.subject.otherPèptidsca
dc.subject.otherProteïnesca
dc.titleThe Masking Game: Design of Activatable Antibodies and Mimetics for Selective Therapeutics and Cell Controlca
dc.typeinfo:eu-repo/semantics/articleca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc616ca
dc.identifier.doihttps://pubs.acs.org/doi/10.1021/acscentsci.0c01448ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/Grant No.844441ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/MCIU/FPU19/03216ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/SGR 2017 1559ca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca


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