Articles publicats en revistes: Envíos recientes
Mostrando ítems 501-520 de 733
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Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
(Neuropharmacology, 2021-03-15)The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present ... -
Zwitterionic self-assembled nanoparticles as carriers for Plasmodium targeting in malaria oral treatment
(Journal of Controlled Release. Vol.331, p.364-375, 2021-03-10)The current decline in antimalarial drug efficacy due to the evolution of resistant Plasmodium strains calls for new strategies capable of improving the bioavailability of antimalarials, especially of ... -
Plasmodium falciparum apicomplexan-specific glucosamine-6-phosphate n-acetyltransferase is key for amino sugar metabolism and asexual blood stage development
(Molecular Biology and Physiology. Vol.11, n.5 (2020), e02045-20, 2020-10)ABSTRACT UDP-N-acetylglucosamine (UDP-GlcNAc), the main product of the hexosamine biosynthetic pathway, is an important metabolite in protozoan parasites since its sugar moiety is incorporated into ... -
A consistent thermodynamic molecular model of n-hydrofluoroolefins and blends for refrigeration applications
(International Journal of Refrigeration. Vol.113 (2020), p.145-155, 2020-05)This work presents a thermodynamic model that characterizes 4th-generation hydrofluoroolefins (HFOs)-based refrigerants with the molecular-based soft-SAFT equation of state (Blas and Vega, 1998) as well ... -
Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas
(Afinidad. Vol.59, n.500 (2002), p.343-356, 2002)La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ... -
Glycosidases and glycosynthases in enzymatic synthesis of oligosaccharides: an overview
(Afinidad. Vol.59, n.500 (2002), p.295-313, 2002)Retaining glycosidases have been extensively studied for the synthesis of oligosaccharides and glycoconjugates as a convenient enzymatic approach to achieve the required regio- and stereoselectivity in ... -
The role of carbon black surface activity and specific surface area in the vulcanization reaction
(Afinidad. Vol.59, n.500 (2002), p.337-342, 2002)This paper reviews the work developed in studying how Carbon Black presence may affect the vulcanization process and the mechanisms by which CB and polymer interact, which has not been completely described ... -
Heteroacoplamientos catalizados por paladio
(Afinidad. Vol.59, n.500 (2002), p.325-336, 2002)Durante los diez últimos años la química del paladio se ha aplicado intensamente en síntesis orgánica debido a su versatilidad y a su gran selectividad. En esta breve revisión se muestran las características ... -
Introducción a la química combinatoria
(Afinidad. Vol.59, n.500 (2002), p.314-324, 2002)Durante los últimos diez años la Química Combinatoria se ha convertido en una técnica usual para el descubrimiento y desarrollo de nuevos productos con actividad biológica. El presente minireview pretende ... -
Preparation and applications of organo-silica hybrid mesoporous silica nanoparticles for the co-delivery of drugs and nucleic acids
(Nanomaterials. Vol.10, n.12 (2020), 2466, 2020-12)Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the ... -
Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish
(Scientific Reports. Vol.9, n.1 (2019), 16467, 2019-11)Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and ... -
Un modèle épistémologique de référence pour la recherche sur l’algèbre élémentaire
(Nouveaux cahiers de la recherche en éducation. Vol.22, n.1 (2020), p.123–144, 2020-06)La théorie anthropologique du didactique attribue un rôle déterminant au questionnement du savoir mathématique et propose comme outil d’analyse l’élaboration de modèles épistémologiques de référence ... -
Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multinational cohort
(PLoS Neglected Tropical Diseases. Vol. 14, n.6 (2020), e0008203, 2020-06)Background Dengue virus (DENV) infections pose one of the largest global barriers to human health. The four serotypes (DENV 1–4) present different symptoms and influence immune response to subsequent ... -
The potential of proteolytic chimeras as pharmalogical tools and therapeutic agents
(Molecules. Vol.25, n.24 (2020), 5956, 2020-12)The induction of protein degradation in a highly selective and efficient way by means of druggable molecules is known as targeted protein degradation (TPD). TPD emerged in the literature as a revolutionary ... -
Role of infill parameters on the mechanical performance and weight reduction of PEI Ultem processed by FFF
(Material & Design. Vol. 193 (2020), 108810, 2020-08)In comparison with conventional manufacturing technologies, Fused Filament Fabrication (FFF) offers countless benefits. It broadens the horizons of the design of structural components with high geometrical ... -
Preparative scale production of recombinant human transthyretin for biophysical studies of protein-ligand and protein-protein interactions
(International Journal of Molecular Sciences. Vol.21, n.24 (2020), 9640, 2020-12)Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial ... -
Zwitterionic 3D-printed non-immunogenic stealth microrobots
(Advanced Materials. Vol.32, n.42 (2020), 2003013, 2020-08)Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a ... -
Screening of ionic liquids and deep eutectic solvents for physical CO2 absorption by soft-SAFT using key performance indicators
(Journal of Chemical and Engineering Data. Vol. 65, n.12 (2020), p.5844-5861, 2020-10)The efficient screening of solvents for CO2 capture requires a reliable and robust equation of state to characterize and compare their thermophysical behavior for the desired application. In this work, ... -
Relationship between marital status and incidence of type 2 diabetes mellitus in a Brazilian rural population: the Baependi heart study
(PLoS One. Vol. 15, n.8 (2020), e0236869, 2020-08)Many factors influence the incidence of type 2 diabetes mellitus (T2DM). Here, we investigated the associations between socio-demographic characteristics and familial history with the 5-year incidence ... -
Stochastic modeling reveals kinetic heterogeneity in post-replication DNA methylation
(PLoS Computational Biology. Vol. 16, n.4 (2020), e1007195, 2020-04)DNA methylation is a heritable epigenetic modification that plays an essential role in mammalian development. Genomic methylation patterns are dynamically maintained, with DNA methyltransferases mediating ...