Browsing Articles publicats en revistes by Subject 

Browsing Articles publicats en revistes by Subject "Nanopartícules"

Now showing items 1-14 of 14

    • A machine learning approach to predict cellular uptake of pBAE polyplexes 

      Loecher, Aparna; Bruyns-Haylett, Michael; Ballester, Pedro J.; Borrós, Salvador; Oliva-Jorge, Nuria (Biomaterials Science 2023, 12(17), 5697-6002, 2023-09)
      The delivery of genetic material (DNA and RNA) to cells can cure a wide range of diseases but is limited by the delivery efficiency of the carrier system. Poly β-amino esters (pBAEs) are promising ...

    • Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas 

      Fornaguera, Cristina; Lázaro, Miguel Ángel; Brugada Vilà, Pau; Porcar, Irene; Morera, Ingrid; Guerra-Rebollo, Marta; Garrido, Cristina; Blanco, Jeronimo; Cascante, Anna; Borrós, Salvador (Drug Delivery, 2018-02-07)
      Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, ...

    • Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy 

      Riera, Roger; Tauler, Jana; Feiner Gracia, Natàlia; Borrós, Salvador; Fornaguera, Cristina; Albertazzi, Lorenzo (ChemMedChem 2022, 17(13), e202100633, 2022)
      Nanomedicine emerged some decades ago with the hope to be the solution for most unmet medical needs. However, tracking materials at nanoscale is challenging to their reduced size, below the resolution ...

    • Detection of peptide-based nanoparticles in blood plasma by ELISA 

      Borrós, Salvador; Bode, Gerard H.; Pickl, Karin E.; Sánchez Purrà, Maria; Albaiges, Berta; Pötgens, Andy J. G.; Schmitz, Christoph; Sinner, Frank M.; Losen, Mario; Steinbusch, Harry W. M.; Frank, Hans-Georg; Martinez-Martinez, Pilar (PLoS ONE. Vol.10, n.5 (2015), e0126136, 2015-05)
      Aims The aim of the current study was to develop a method to detect peptide-linked nanoparticles in blood plasma. Materials & Methods A convenient enzyme linked immunosorbent assay (ELISA) was developed ...

    • Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells 

      Fornaguera, Cristina; Borrós, Salvador; Salinas, Yolanda; Kneidinger, Michael; Bruggemann, Oliver; Teasdale, Ian (RSC Advances. Vol.10, n.46 (2020), p.27305-27314, 2020-07)
      A switchable silane derived stimuli-responsive bottle-brush polyphosphazene (PPz) was prepared and attached to the surface of mesoporous silica nanoparticles (MSNs). The hybrid polymer with PEG-like ...

    • Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection 

      Guerra-Rebollo, Marta; Stampa, María; Lázaro, Miguel Ángel; Cascante, Anna; Fornaguera, Cristina; Borrós, Salvador (Journal of Neuromuscular Diseases, vol. 8, no. 5, pp. 815-825, 2021-09-14)
      Background:Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. ...

    • Extracellular vesicles and their current role in cancer immunotherapy 

      Giacobino, Carla; Canta, Marta; Fornaguera, Cristina; Borrós, Salvador; Cauda, Valentina (Cancers, 2021-05-10)
      Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ...

    • Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles 

      Fernandez Alarcon, Jennifer; Perez Schmidt, Patricia; Panini, Nicolò; Caruso, Francesca; Violatto, Martina Bruna; SUKUBO, NATHS GRAZIA; Martinez-Serra, Alberto; Ekalle Soppo, Charlotte Blanche ; Morelli, Annalisa; Moscatiello, Giulia Yuri; Grasselli, Chiara; Corbelli, Alessandro; Fiordaliso, Fabio; Kelk, Joe; PETROSILLI, LAURA; D'ORAZIO, GIUSEPPE; Mateu Ferrando, Ruth; Verdaguer, Ariadna; Fornaguera, Cristina; LAY, LUIGI; Fumagalli, Stefano; RECCHIA, SANDRO; Monopoli, Marco P.; Bigini, Paolo; Sitia, Giovanni (Advanced Science 2025, 12 (16), 2025-04-24)
      Macrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer-promoting activity or trigger anti-inflammatory ...

    • Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles for the co-delivery of DOX/CPT-PEG for targeting HepG2 cells 

      Sánchez-García, David; Borrós, Salvador; Fornaguera, Cristina; Martínez Edo, Gabriel (Pharmaceutics. Vol.12, n.11 (2020), 1048, 2020-11)
      A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles ...

    • Nanostructured AABB Zn (II) Phthalocyanines as Photodynamic Agents for Bacterial Inactivation 

      Paramio, Irene; Salazar, Ainhoa; Jordà Redondo, Mireia; Nonell, Santi; Torres, Tomás; De la Torre, Gema (Advanced Therapeutics 2023, 6 (11), 2300116, 2023-11)
      In this work, the ability of amphiphilic Phthalocyanine (Pc) photosensitizers (PS) (Zn(II)Pcs PS1, PS2, and PS3) to assemble into cationic nanoparticles in water and to photo-inactivate bacterial strains ...

    • PEI-mediated transient transfection of high five cells at bioreactor scale for HIV-1 VLP production 

      Lecina, Martí; Puente-Massaguer, Eduard; Strobl, Florian; Grabherr, Reingard; Striedner, Gerald; Gòdia, Francesc (Nanomaterials. Vol.10, n.8 (2020), 1580, 2020-08)
      High Five cells are an excellent host for the production of virus-like particles (VLPs) with the baculovirus expression vector system (BEVS). However, the concurrent production of high titers of baculovirus ...

    • Preparation and applications of organo-silica hybrid mesoporous silica nanoparticles for the co-delivery of drugs and nucleic acids 

      Sánchez-García, David; Pontón, Iris; Martí del Rio, Andrea; Gómez Gómez, Marta (Nanomaterials. Vol.10, n.12 (2020), 2466, 2020-12)
      Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the ...

    • Simple generation of human induced pluripotent stem cells using poly-β-amino esters as the non-viral gene delivery system 

      Borrós, Salvador; Ramos Pérez, Víctor; Gutiérrez, Jordán; Izpisúa Belmonte, J. C.; Montserrat, Núria; Garreta, Elena; González, Federico; Eguizábal, Cristina (Journal of Biological Chemistry. Vol.286,n.14 (2011),p.12417-12428, 2011-04)
      Reprogramming of somatic cells to induced pluripotent stem (iPS) cells can be achieved by the delivery of a combination of transcription factors, including Oct4, Sox2, Klf4, and c-Myc. Retroviral and ...

    • The primeval optical evolving matter by optical binding inside and outside the photon beam 

      Huang, Chih-Hao; Louis, Boris; Bresolí Obach, Roger; Kudo, Tetsuhiro; Camacho, Rafael; Scheblykin, Ivan; Sugiyama, Teruki; Hofkens, Johan; Masuhara, Hiroshi (Nature Communications 2022, 13(1), 5325, 2022)
      Optical binding has recently gained considerable attention because it enables the light-induced assembly of many-body systems; however, this phenomenon has only been described between directly irradiated ...