Visualitzant Articles publicats en revistes per matèria "615"

Ara mostrant els elements 1-18 de 18

    • Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion 

      Faria, Melissa; Prats, Eva; Rosas Ramírez, Jonathan Ricardo; Bellot, Marina; Bedrossiantz, Juliette; Pagano, Maria; Valls, Arnau; Gómez Canela, Cristian; Porta, Josep M; Mestres, Jordi; Garcia-Reyero, Natàlia; Faggio, Caterina; Gómez-Oliván, Leobardo Manuel; Raldua, Demetrio (Science of the Total Environment, 2021-06-25)
      Fenitrothion is an organophosphorus insecticide usually found in aquatic ecosystems at concentrations in the range of low ng/L. In this manuscript we show that 24 h exposure to environmental concentrations ...

    • Aqueous stability and degradation of psychiatric and neuroactive compounds and its biological activity in Daphnia magna 

      Bellot, Marina; Barata, Carlos; Gómez Canela, Cristian (Science of the Total Environment, 2021-07-28)
      Pharmaceuticals and other emerging contaminants are continuously released into the aquatic environment, considered as ‘pseudo-persistent’ pollutants. Many compounds degrade fast in the environment, but ...

    • Bactericidal effect of photodynamic therapy, alone or in combination with mupirocin or linezolid, on Staphylococcus aureus 

      Nonell, Santi; Pérez-Laguna, Vanesa; Pérez-Artiaga, Luna; Lampaya-Pérez, Verónica; García-Luque, Isabel; Ballesta, Sofía; Paz-Cristobal, Manuel P.; Gilaberte, Yolanda; Rezusta, Antonio (Frontiers in Microbiology. Vol. 8 (2017), 1002, 2017-05)
      Antibiotic treatments frequently fail due to the development of antibiotic resistance, underscoring the need for new treatment strategies. Antimicrobial photodynamic therapy (aPDT) could constitute an ...

    • Carminic acid linked to silica nanoparticles as pigment/antioxidant bifunctional excipient for pharmaceutical emulsions 

      Nonell, Santi; Morales, Javier; Arriagada, Francisco; Ugarte, Catalina; Günther, Germán; Larraín, María Angélica; Guarnizo-Herrero, Víctor (Pharmaceutics. Vol.12, n.4 (2020), 376, 2020-04)
      The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant ...

    • Extracellular vesicles and their current role in cancer immunotherapy 

      Giacobino, Carla; Canta, Marta; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Cauda, Valentina (Cancers, 2021-05-10)
      Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ...

    • Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety 

      Faria, Melissa; Bedrossiantz, Juliette; Rosas Ramírez, Jonathan Ricardo; Mayol, Marta; Heredia García, Gerardo; Bellot, Marina; Prats, Eva; Garcia-Reyero, Natàlia; Gómez Canela, Cristian; Gómez-Oliván, Leobardo Manuel; Raldua, Demetrio (Environment International, 2020-11-18)
      Glyphosate is the active ingredient of some of the most highly produced and used herbicides worldwide. The intensive applications of glyphosate-based herbicides and its half-life in water lead to its ...

    • Industria farmacéutica 4.0 

      Sempere Cebrián, Julià; Nomen i Ribé, Rosa (Pharmatech. N.42 (marzo-abril 2019), p.79-82, 2019-03)
      La implantación de las tecnologías de la industria 4.0 va a producir grandes cambios en la industria química y farmacéutica. Disponer de un modelo claro de lo qué es la industria 4.0 es clave para ...

    • Introducción a la química combinatoria 

      Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Falcó, José Luis; Pascual, Rosalía (Afinidad. Vol.59, n.500 (2002), p.314-324, 2002)
      Durante los últimos diez años la Química Combinatoria se ha convertido en una técnica usual para el descubrimiento y desarrollo de nuevos productos con actividad biológica. El presente minireview pretende ...

    • Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator 

      Nonell, Santi; Bresolí Obach, Roger; Font Inglès, Joan; López-Cano, Marc; Notartomaso, Serena; Scarselli, Pamela; Di Pietro, Paola; Battaglia, Giuseppe; Malhaire, Fanny; Rovira, Xavier; Catena, Juanlo; Giraldo, Jesús; Pin, Jean-Philippe; Fernández-Dueñas, Víctor; Goudet, Cyril; Nicoletti, Ferdinando; Llebaria, Amadeu; Ciruela, Francisco (eLIFE. Vol.6 (2017), e23545, 2017-04)
      Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive ...

    • Pharmacological modulation of behaviour, serotonin and dopamine levels in daphnia magna exposed to the monoamine oxidase inhibitor deprenyl 

      Bellot, Marina; Faria, Melissa; Gómez Canela, Cristian; Raldúa, Demetrio; Barata, Carlos (Toxics, 2021-08-09)
      This study assessed the effects of the monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms of action of deprenyl were also determined by studying the relationship ...

    • Pharmacological modulation of serotonin levels in zebrafish larvae: lessons for identifying environmental neurotoxicants targeting the serotonergic system 

      Faria, Melissa; Prats, Eva; Bellot, Marina; Gómez Canela, Cristian; Raldúa, Demetrio (Toxics, 2021-05-25)
      This study examines the effects of acute pharmacological modulation of the serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput ...

    • Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas 

      Nonell, Santi; Sánchez García, David; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Arad, Ofir; Gavaldá, Ana; Rey, Óscar; Rubio, Noemi; Cañete, Magdalena; Juarranz, Angeles; Villanueva, Angeles; Stockert, Juan C.; Díaz Jiménez, Pablo J. (Afinidad. Vol.59, n.500 (2002), p.343-356, 2002)
      La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ...

    • Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones 

      Duart-Castells, L.; Nadal Gratacós, Núria; Muralter, M.; Puster, B.; Berzosa Rodríguez, Xavier; Estrada Tejedor, Roger; Niello, M.; Bhat, S.; Pubill Sánchez, David; Camarasa, J.; Sitte, H. H.; Escubedo, E.; López-Arnau, R. (Neuropharmacology, 2021-03-15)
      The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present ...

    • Role of Survivin in Bladder Cancer: Issues to Be Overcome When Designing an Efficient Dual Nano-Therapy 

      Arista Romero, Maria; Cascante, Anna; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador (Pharmaceutics, 2021-11-19)
      Bladder cancer is the 10th most diagnosed cancer, with almost 10 M cancer deaths last year worldwide. Currently, chemotherapy is widely used as adjuvant therapy after surgical transurethral resection. ...

    • Structural implications of the DFD-in domain in computer-aided molecular design of MAP kinase interacting kinase 2 inhibitors 

      Estrada Tejedor, Roger; Bou Petit, Elisabeth; Borrell Bilbao, José Ignacio; Ramón y Cajal, S. (Afinidad. Vol.74, n.578 (2017), p.83-89, 2017-04)
      Protein translation is a key process on cell development and proliferation that is often deregulated in cancer. MAP kinase interacting kinases 1 and 2 (Mnk1/2) play a pivotal role in regulating the ...

    • Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish 

      Gómez Canela, Cristian; Faria, Melissa; Prats, Eva; Hsu, Chuan-Yu; Arick, Mark A. II; Bedrossiantz, Juliette; Orozco, Manuel; Garcia-Reyero, Natàlia; Ziv, Tamar; Ben-Lulu, Shani; Admon, Arie; Gómez-Oliván, Leonardo Manuel; Raldúa, Demetrio (Scientific Reports. Vol.9, n.1 (2019), 16467, 2019-11)
      Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and ...

    • Two-component systems of mycobacterium tuberculosis as potential targets for drug development 

      Planas, Antoni (Planas Sauter); Pellicer Moya, Maria Teresa; Marszalek, Marta (Afinidad. Vol.71, n.567 (2014), p.172-178, 2014-07)
      Tuberculosis, caused by Mycobacterium tuberculosis, is a global health problem with approximately two million deaths every year. Furthermore, up to one-third of the world population is infected with ...

    • Zwitterionic self-assembled nanoparticles as carriers for Plasmodium targeting in malaria oral treatment 

      Biosca, Arnau; Cabanach Xifró, Pol; Abdulkarim, Muthanna; Gumbleton, Mark; Gómez Canela, Cristian; ramírez moreno, miriam; Bouzón-Arnáiz, Inés; Avalos-Padilla, Yunuen; Borrós i Gómez, Salvador; Fernàndez-Busquets, Xavier (Journal of Controlled Release. Vol.331, p.364-375, 2021-03-10)
      The current decline in antimalarial drug efficacy due to the evolution of resistant Plasmodium strains calls for new strategies capable of improving the bioavailability of antimalarials, especially of ...