Listando Articles publicats en revistes por título
Mostrando ítems 216-235 de 256
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Stochastic modeling reveals kinetic heterogeneity in post-replication DNA methylation
(PLoS Computational Biology. Vol. 16, n.4 (2020), e1007195, 2020-04)DNA methylation is a heritable epigenetic modification that plays an essential role in mammalian development. Genomic methylation patterns are dynamically maintained, with DNA methyltransferases mediating ... -
Structural analysis of an automotive interior system: practical learning in the context of the new EHEA
(DYNA. Vol.91 (May 2016), p.272-276, 2016-05)At the IQS School of Engineering, practices has been implemented that bring students to the industrial environment through real cases. This action is in accordance with the philosophy of the European ... -
Structural implications of the DFD-in domain in computer-aided molecular design of MAP kinase interacting kinase 2 inhibitors
(Afinidad. Vol.74, n.578 (2017), p.83-89, 2017-04)Protein translation is a key process on cell development and proliferation that is often deregulated in cancer. MAP kinase interacting kinases 1 and 2 (Mnk1/2) play a pivotal role in regulating the ... -
Structural-functional analysis reveals a specific domain organization in family GH20 hexosaminidases
(PLoS ONE. Vol.10, n.5 (2015), e0128075, 2015-05)Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates. The GH20 enzymes present diverse ... -
Structure-function features of a mycoplasma glycolipid synthase derived from structural data integration, molecular simulations, and mutational analysis
(PLoS One. Vol.8, n.12 (2013), e81990, 2013-12)Glycoglycerolipids are structural components of mycoplasma membranes with a fundamental role in membrane properties and stability. Their biosynthesis is mediated by glycosyltransferases (GT) that catalyze ... -
Subdiffraction localization of a nanostructured photosensitizer in bacterial cells
(Scientific Reports. Vol.5, 15564 (2015), 2015-10)Antibacterial treatments based on photosensitized production of reactive oxygen species is a promising approach to address local microbial infections. Given the small size of bacterial cells, identification ... -
Substrate distortion in the Michaelis complex of Bacillus 1,3–1,4-β-glucanase: insight from first principles molecular dynamics simulations
(Journal of Biological Chemistry. Vol.281, n.3 (2006), p.1432–1441, 2006-01)The structure and dynamics of the enzyme-substrate complex of Bacillus 1,3–1,4-β-glucanase, one of the most active glycoside hydrolases, is investigated by means of Car-Parrinello molecular dynamics ... -
Sustainable development: The stock market's view of environmental policy
(Business Strategy and the Environment, 2020-07-08)This study applies panel data regression models to investigate how the stock market values the environmental policy of the firm. The empirical analysis relies on a cross-country sample of public firms ... -
Syndecans and Pancreatic Ductal Adenocarcinoma
(Biomolecules, 2021-02-25)Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because patients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a ... -
Synthesis, photophysical characterization and photoinduced antibacterial activity of methylene blue-loaded amino- and mannose-targeted mesoporous silica nanoparticles
(Molecules. Vol.20, n.4 (2015), p.6284-6298, 2015-04)Over the last 20 years, the number of pathogenic multi-resistant microorganisms has grown steadily, which has stimulated the search for new strategies to combat antimicrobial resistance. Antimicrobial ... -
Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease
(European Journal of Medicinal Chemistry, 2021-12-15)Transthyretin (TTR) has a well-established role in neuroprotection in Alzheimer's Disease (AD). We have setup a drug discovery program of small-molecule compounds that act as chaperones enhancing ... -
Teaching Cheminformatics through a Collaborative Intercollegiate Online Chemistry Course (OLCC)
(Journal of Chemical Education, 2020-12-21)While cheminformatics skills necessary for dealing with an ever-increasing amount of chemical information are considered important for students pursuing STEM careers in the age of big data, many schools ... -
Tetramethylbenzidine: an acoustogenic photoacoustic probe for reactive oxygen species detection
(Sensors. Vol.20, n.20 (2020), 5952, 2020-10)Photoacoustic imaging is attracting a great deal of interest owing to its distinct advantages over other imaging techniques such as fluorescence or magnetic resonance image. The availability of photoacoustic ... -
The anthropological function of dialogue in political reconciliation processes: ethical analysis of Ignacio Ellacuría's thought on the 25th anniversary of his death (1989-2014)
(Ramon Llull Journal of Applied Ethics, Núm. 5 (2014), p.125-141, 2014)The idea of a just and lasting peace seems to be unachievable when people are suffering a civil or international war, a violent revolutionary process or a dictatorship, or when they are immersed in a ... -
The external didactic transposition of mathematics at university level: dilemmas and challenges
(Educaçao Matemática Pesquisa. Vol.22, n.4 (2020) p.373-386, 2020)We develop the idea that research on university mathematics education needs to more systematically address the external didactic transposition. After outlining existing research that goes more or less ... -
The impact of the perceived risk of COVID-19 on consumers' attitude and behavior toward locally produced food
(British Food Journal, 2021-12-17)Purpose This study analyzes the impact of the COVID-19 pandemic on the consumption of locally produced food. In particular, it examines an extended model of the theory of planned behavior, with the ... -
The influence of the trade-off between profitability and future increases in sales on cost stickiness
(Estudios de Economía. Vol. 44, No.1 (2017), pág. 81-104, 2017-06)This study analyses cost stickiness under the dilemma between current profitability and future sales increase. When activity decreases firms are faced to keep profitability adjusting resources, while ... -
The interaction effects of firm and partner tenure on audit quality
(Accounting and Business Research. Vol.47, n.7 (2017), p.810-830, 2017-02)This paper investigates the impact of firm and partner tenure on audit quality, where audit quality is proxied by discretionary accruals. We study a sample of Spanish listed companies between 2005 and ... -
The Masking Game: Design of Activatable Antibodies and Mimetics for Selective Therapeutics and Cell Control
(ACS Central Science, 2021-04-26)The high selectivity and affinity of antibody binding havemade antibodies all-pervasive tools in therapy, diagnosis, and basic science.A plethora of chemogenetic approaches has been devised to makeantibodies ... -
The potential of proteolytic chimeras as pharmalogical tools and therapeutic agents
(Molecules. Vol.25, n.24 (2020), 5956, 2020-12)The induction of protein degradation in a highly selective and efficient way by means of druggable molecules is known as targeted protein degradation (TPD). TPD emerged in the literature as a revolutionary ...