Browsing Articles publicats en revistes by Author "Borrell Bilbao, José Ignacio"

Now showing items 1-9 of 9

    • Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma 

      Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Puig de la Bellacasa Cazorla, Raimon; Roué, Gaël; Balsas, P.; Esteve-Arenys, A.; Roldán, J.; Jiménez, L.; Rodríguez, V.; Valero, J. G.; Chamorro-Jorganes, A.; Matas-Céspedes, A.; Moros, A.; Martínez, A.; Campo, E.; Sáez-Borderías, A.; Pérez-Galán, P.; Colomer, D. (Journal of Hematology & Oncology. Vol.10, n.80 (2017), 2017-03)
      Background Pharmacological inhibition of B cell receptor (BCR) signaling has recently emerged as an effective approach in a wide range of B lymphoid neoplasms. However, despite promising clinical activity ...

    • Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1 

      Ondono, Raul; Lirio, Ángel; Carlos, Elvira; Álvarez-Marimon, Elena; Provenzano, Claudia; Cardinali, Beatrice; Pérez-Alonso, Manuel; Perálvarez-Marín, Alex; Borrell Bilbao, José Ignacio; Falcone, Germana; Estrada Tejedor, Roger (Computational and Structural Biotechnology Journal, 2020-11-28)
      Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity ...

    • Heteroacoplamientos catalizados por paladio 

      Teixidó i Closa, Jordi; Sánchez García, David; Borrós i Gómez, Salvador; Nonell, Santi; Borrell Bilbao, José Ignacio; Colominas Guàrdia, Carles (Afinidad. Vol.59, n.500 (2002), p.325-336, 2002)
      Durante los diez últimos años la química del paladio se ha aplicado intensamente en síntesis orgánica debido a su versatilidad y a su gran selectividad. En esta breve revisión se muestran las características ...

    • In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models 

      Estrada Tejedor, Roger; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; González, Àlex L.; Konieczn, Piotr; Llamusi, Beatriz; Delgado-Pinar, Estefanía; García-España, Enrique; Pérez-Alonso, Manuel; Artero, Rubén (PLoS ONE. Vol.12, n.6 (2017), e0178931, 2017-06)
      Myotonic dystrophy type 1 (DM1) is a rare multisystemic disorder associated with an expansion of CUG repeats in mutant DMPK (dystrophia myotonica protein kinase) transcripts; the main effect of these ...

    • Introducción a la química combinatoria 

      Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Falcó, José Luis; Pascual, Rosalía (Afinidad. Vol.59, n.500 (2002), p.314-324, 2002)
      Durante los últimos diez años la Química Combinatoria se ha convertido en una técnica usual para el descubrimiento y desarrollo de nuevos productos con actividad biológica. El presente minireview pretende ...

    • Molecular basis of the selective binding of MDMA enantiomers to the Alpha4Beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies 

      Borrell Bilbao, José Ignacio; Llabrés Prat, Salomé; García-Ratés, Sara; Cristóbal Lecina, Edgar; Riera i Escalé, Antoni; Camarasa García, Jordi; Pubill Sánchez, David; Luque Garriga, F. Xavier; Escubedo Rafa, Elena (European Journal of Medicinal Chemistry. Vol.81 (2014), p.35-46, 2014-06)
      The α4β2 nicotinic acetylcholine receptor (nAChR) is a molecular target of 3,4-methylenedioxymethamphetamine (MDMA), a synthetic drug also known as ecstasy, and it modulates the MDMA-mediated reinforcing ...

    • Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors 

      Borrell Bilbao, José Ignacio; Puig de la Bellacasa Cazorla, Raimon; Gibert Bosch, Albert; Planesas, Jesús M.; Ros Blanco, Laia; Batllori Aguilà, Xavier; Badía, Roger; Clotet i Sala, Bonaventura; Esté, José A.; Teixidó i Closa, Jordi (Organic & Biomolecular Chemistry. Vol.14, n.4 (2016), p.1455-1472, 2015-12)
      The paradigm, derived from bicyclams and other cyclams, by which it is necessary to use the p-phenylene moiety as the central core in order to achieve high HIV-1 antiviral activities has been reexamined ...

    • Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas 

      Nonell, Santi; Sánchez García, David; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Arad, Ofir; Gavaldá, Ana; Rey, Óscar; Rubio, Noemi; Cañete, Magdalena; Juarranz, Angeles; Villanueva, Angeles; Stockert, Juan C.; Díaz Jiménez, Pablo J. (Afinidad. Vol.59, n.500 (2002), p.343-356, 2002)
      La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ...

    • Structural implications of the DFD-in domain in computer-aided molecular design of MAP kinase interacting kinase 2 inhibitors 

      Estrada Tejedor, Roger; Bou Petit, Elisabeth; Borrell Bilbao, José Ignacio; Ramón y Cajal, S. (Afinidad. Vol.74, n.578 (2017), p.83-89, 2017-04)
      Protein translation is a key process on cell development and proliferation that is often deregulated in cancer. MAP kinase interacting kinases 1 and 2 (Mnk1/2) play a pivotal role in regulating the ...