Browsing IQS by Issue Date
Now showing items 221-240 of 257
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Differential modulation of the central and peripheral monoaminergic neurochemicals by deprenyl in Zebrafish Larvae
(Toxics, 2021-05-23)Zebrafish embryos and larvae are vertebrate models increasingly used in translational neuroscience research. Behavioral impairment induced by the exposure to neuroactive or neurotoxic compounds is ... -
Pharmacological modulation of serotonin levels in zebrafish larvae: lessons for identifying environmental neurotoxicants targeting the serotonergic system
(Toxics, 2021-05-25)This study examines the effects of acute pharmacological modulation of the serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput ... -
Experimental, computational, and dimensional analysis of the mechanical performance of fused filament fabrication parts
(Polymers, 2021-05-27)Process parameters in Additive Manufacturing (AM) are key factors in the mechanical performance of 3D-printed parts. In order to study their effect, a three-zone model based on the printing pattern was ... -
Prospects on coupling UV/H2O2 with activated sludge or a fungal treatment for the removal of pharmaceutically active compounds in real hospital wastewater
(Science of the Total Environment, 2021-06-15)Conventional active sludge (AS) process at municipal centralized wastewater treatment facilities may exhibit little pharmaceuticals (PhACs) removal efficiencies when treating hospital wastewater (HWW). ... -
Analytical parameters of a novel glucose biosensor based on grafted PFM as a covalent immobilization technique
(Sensors, 2021-06-15)Bioanalytical methods, in particular electrochemical biosensors, are increasingly used in different industrial sectors due to their simplicity, low cost, and fast response. However, to be able to reliably ... -
A Poset-Generalizability Method for Human Development Indicators
(Social Indicators Research, 2021-06-17)The paper introduces a poset-generalizability perspective for analysing human development indicators. It suggests a new method for identifying admissibility of diferent informational spaces and criteria ... -
Creation of Ionically Crosslinked Tri-Layered Chitosan Membranes to Simulate Different Human Skin Properties
(Materials, 2021-06-23)In 2023, new legislation will ban the use of animals in the cosmetic industry worldwide. This fact, together with ethical considerations concerning the use of animals or humans in scientific research, ... -
Simulation Approach for Hydrophobicity Replication via Injection Molding
(Polymers, 2021-06-23)Nanopattern replication of complex structures by plastic injection is a challenge that requires simulations to define the right processing parameters. Previous work managed to simulate replication for ... -
Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion
(Science of the Total Environment, 2021-06-25)Fenitrothion is an organophosphorus insecticide usually found in aquatic ecosystems at concentrations in the range of low ng/L. In this manuscript we show that 24 h exposure to environmental concentrations ... -
Exploring benzylic gem-C(sp3)–boron–silicon and boron–tin centers as a synthetic platform
(Chemical Science, 2021-07-02)A stepwise build-up of multi-substituted Csp3 carbon centers is an attractive, conceptually simple, but often synthetically challenging type of disconnection. To this end, this report describes how ... -
Aqueous stability and degradation of psychiatric and neuroactive compounds and its biological activity in Daphnia magna
(Science of the Total Environment, 2021-07-28)Pharmaceuticals and other emerging contaminants are continuously released into the aquatic environment, considered as ‘pseudo-persistent’ pollutants. Many compounds degrade fast in the environment, but ... -
Pharmacological modulation of behaviour, serotonin and dopamine levels in daphnia magna exposed to the monoamine oxidase inhibitor deprenyl
(Toxics, 2021-08-09)This study assessed the effects of the monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms of action of deprenyl were also determined by studying the relationship ... -
Erlotinib Promotes Ligand-Induced EGFR Degradation in 3D but Not 2D Cultures of Pancreatic Ductal Adenocarcinoma Cells
(Cancers, 2021-09-07)The epithelial growth factor receptor (EGFR) is a tyrosine kinase receptor that participates in many biological processes such as cell proliferation. In addition, EGFR is overexpressed in many epithelial ... -
Nb–C thin films prepared by DC-MS and HiPIMS: Synthesis, structure, and tribomechanical properties
(Surface and Coatings Technology. Vol.422 (2021), 127569, 2021-09-25)Nanostructured Nb-C thin films were prepared by direct current magnetron sputtering (DC-MS) and high-power impulse magnetron sputtering (HiPIMS). The films were characterized in depth by X-ray diffraction ... -
Defined D-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease
(Scientific Reports, 2021-09-30)In Myotonic Dystrophy type 1 (DM1), a non-coding CTG repeats rare expansion disease; toxic double-stranded RNA hairpins sequester the RNA-binding proteins Muscleblind-like 1 and 2 (MBNL1 and 2) and ... -
Mechanical performance of 3D-printed biocompatible polycarbonate for biomechanical applications
(Polymers. Vol.13, n.21 (2021), 3669, 2021-10)Additive manufacturing has experienced remarkable growth in recent years due to the customisation, precision, and cost savings compared to conventional manufacturing techniques. In parallel, materials ... -
Mandatory joint audit and audit quality in the context of the European blue chips
(Journal of Business Economics & Management, 2021-10-13)This study investigates audit quality under joint and single audit regimes with a sample of large European firms. Both, the economic relevance of these companies, and the fact that the impact of joint ... -
Role of Survivin in Bladder Cancer: Issues to Be Overcome When Designing an Efficient Dual Nano-Therapy
(Pharmaceutics, 2021-11-19)Bladder cancer is the 10th most diagnosed cancer, with almost 10 M cancer deaths last year worldwide. Currently, chemotherapy is widely used as adjuvant therapy after surgical transurethral resection. ... -
Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease
(European Journal of Medicinal Chemistry, 2021-12-15)Transthyretin (TTR) has a well-established role in neuroprotection in Alzheimer's Disease (AD). We have setup a drug discovery program of small-molecule compounds that act as chaperones enhancing ... -
The impact of the perceived risk of COVID-19 on consumers' attitude and behavior toward locally produced food
(British Food Journal, 2021-12-17)Purpose This study analyzes the impact of the COVID-19 pandemic on the consumption of locally produced food. In particular, it examines an extended model of the theory of planned behavior, with the ...