Browsing IQS by Issue Date
Now showing items 201-220 of 257
-
The potential of proteolytic chimeras as pharmalogical tools and therapeutic agents
(Molecules. Vol.25, n.24 (2020), 5956, 2020-12)The induction of protein degradation in a highly selective and efficient way by means of druggable molecules is known as targeted protein degradation (TPD). TPD emerged in the literature as a revolutionary ... -
Smart dual-functionalized gold nanoclusters for spatio-temporally controlled delivery of combined chemo- and photodynamic therapy
(Nanomaterials. Vol.10, n.12 (2020), 2474, 2020-12)We report the preparation of gold nanoclusters (AuNCs) as a delivery vehicle for the clinically approved photodynamic and chemotherapeutic agents Protoporphyrin IX (PpIX) and doxorubicin (DOX), respectively, ... -
Triglyceride glucose index as a tool to motivate early lifestyle modification in young adults at diabetes risk: the baependi heart study
(Preventive medicine reports. Vol.20 (2020), 101172, 2020-12)Considering that the incidence of type 2 diabetes mellitus (T2DM) has been increasing especially in developing countries and becoming a global public health problem, this study aims to evaluate the ... -
Preparation and applications of organo-silica hybrid mesoporous silica nanoparticles for the co-delivery of drugs and nucleic acids
(Nanomaterials. Vol.10, n.12 (2020), 2466, 2020-12)Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the ... -
Passive, non-systematic search as an alternative to systematic search in opportunity discovery
(Harvard Deusto Business Research. Vol.IX, n.2 (2020) p.110-128, 2020-12)This paper summarizes the results of a multiple-case study conducted to shed light into the question of how business opportunities are recognized by examining two theoretical propositions related to two ... -
Preparative scale production of recombinant human transthyretin for biophysical studies of protein-ligand and protein-protein interactions
(International Journal of Molecular Sciences. Vol.21, n.24 (2020), 9640, 2020-12)Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial ... -
Teaching Cheminformatics through a Collaborative Intercollegiate Online Chemistry Course (OLCC)
(Journal of Chemical Education, 2020-12-21)While cheminformatics skills necessary for dealing with an ever-increasing amount of chemical information are considered important for students pursuing STEM careers in the age of big data, many schools ... -
Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
(Scientific Reports. Vol.11, 1403 (2021), 2021-01)Changes in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance ... -
High-efficacy subcellular micropatterning of proteins using fibrinogen anchors
(Journal of Cell Biology, 2021-01-08)Protein micropatterning allows proteins to be precisely deposited onto a substrate of choice and is now routinely used in cell biology and in vitro reconstitution. However, drawbacks of current technology ... -
Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
(Scientific Reports, 2021-01-14)Changes in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance ... -
Combining biological processes with UV/H2O2 for metoprolol and metoprolol acid removal in hospital wastewater
(Chemical Engineering Journal, 2021-01-15)The transformation products (TPs) of water contaminants generated during wastewater treatment can sometimes be equally or even more hazardous than the parent compounds. Therefore, for a comprehensive ... -
In the opinion of scientists: are there rules in research? Pilot study on the most widespread rules of scientific research
(2021-01-31)Sociologists, ethnologists, philosophers among others have tried to identify the norms or rules that govern scientific research; however, so far, they have not been widely accepted by scientists. This ... -
Syndecans and Pancreatic Ductal Adenocarcinoma
(Biomolecules, 2021-02-25)Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because patients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a ... -
The sequential action of MIDA9/PP2C.D1, PP2C.D2, and PP2C.D5 is necessary to form and maintain the hook after germination in the dark
(Frontiers in Plant Science, 2021-03-09)During seedling etiolation after germination in the dark, seedlings have closed cotyledons and form an apical hook to protect the meristem as they break through the soil to reach the surface. Once in ... -
Zwitterionic self-assembled nanoparticles as carriers for Plasmodium targeting in malaria oral treatment
(Journal of Controlled Release. Vol.331, p.364-375, 2021-03-10)The current decline in antimalarial drug efficacy due to the evolution of resistant Plasmodium strains calls for new strategies capable of improving the bioavailability of antimalarials, especially of ... -
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
(Neuropharmacology, 2021-03-15)The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present ... -
Transglycosylation Activity of Engineered Bifidobacterium Lacto-N-Biosidase Mutants at Donor Subsites for Lacto-N-Tetraose Synthesis
(International Journal of Molecular Sciences, 2021-03-21)The health benefits of human milk oligosaccharides (HMOs) make them attractive targets as supplements for infant formula milks. However, HMO synthesis is still challenging and only two HMOs have been ... -
The Masking Game: Design of Activatable Antibodies and Mimetics for Selective Therapeutics and Cell Control
(ACS Central Science, 2021-04-26)The high selectivity and affinity of antibody binding havemade antibodies all-pervasive tools in therapy, diagnosis, and basic science.A plethora of chemogenetic approaches has been devised to makeantibodies ... -
Extracellular vesicles and their current role in cancer immunotherapy
(Cancers, 2021-05-10)Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ... -
An Ultra-Long-Lived Triplet Excited State in Water at Room Temperature: Insights on the Molecular Design of Tridecafullerenes
(Angewandte Chemie International Edition, 2021-05-13)Suitably engineered molecular systems exhibiting triplet excited states with very long lifetimes are important for high-end applications in nonlinear optics, photocatalysis, or biomedicine. We report ...