Browsing IQS by Author "Camarasa, Jordi"
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3,4-Methylenedioxy methamphetamine, synthetic cathinones and psychedelics: From recreational to novel psychotherapeutic drugs
López-Arnau, Raúl; Camarasa, Jordi; Carbó, Marcel·lí; Nadal Gratacós, Núria; Puigseslloses, Pol; Espinosa Velasco, María; Urquizu, Edurne; Fonseca, David; Pubill, David (Frontiers in Psychiatry, 2022)The utility of classical drugs used to treat psychiatric disorders (e.g., antidepressants, anxiolytics) is often limited by issues of lack of efficacy, delayed onset of action or side effects. Psychoactive ... -
Behavioural and neurochemical effects after repeated administration of N-ethylpentylone (ephylone) in mice
Espinosa Velasco, María; Reguilón, Marina D.; Bellot, Marina; Nadal Gratacós, Núria; Berzosa Rodríguez, Xavier; Puigseslloses, Pol; Gómez Canela, Cristian; Rodríguez Arias, Marta; Pubill, David; Camarasa, Jordi; Fonseca, David; López-Arnau, Raúl (Journal of Neurochemistry, 2022, 160(2), 218-233, 2022)N-ethyl-pentylone (NEP), also known as ‘ephylone’ and N-ethylnorpentylone, has been identified as one of the most recent novel psychostimulants to emerge into the illicit drug market and it has been ... -
Molecular basis of the selective binding of MDMA enantiomers to the Alpha4Beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies
Borrell Bilbao, José Ignacio; Llabrés Prat, Salomé; García-Ratés, Sara; Cristóbal Lecina, Edgar; Riera i Escalé, Antoni; Camarasa, Jordi; Pubill, David; Luque, F. Javier; Fonseca, David (European Journal of Medicinal Chemistry. Vol.81 (2014), p.35-46, 2014-06)The α4β2 nicotinic acetylcholine receptor (nAChR) is a molecular target of 3,4-methylenedioxymethamphetamine (MDMA), a synthetic drug also known as ecstasy, and it modulates the MDMA-mediated reinforcing ... -
Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (“flakka”) Derivatives
Nadal Gratacós, Núria; Lleixà, Esther; Gibert Serramià, Mónica; Estrada Tejedor, Roger; Berzosa Rodríguez, Xavier; Batllori Aguilà, Xavier; Pubill, David; Camarasa, Jordi; Fonseca, David; López-Arnau, Raúl (International Journal of Molecular Sciences 2022, 23(4), 2226, 2022-02)Changes in the molecular structure of synthetic cathinones has led to an increase in the number of novel emerging drugs in the illicit drug market at an unprecedented rate. Unfortunately, little is known ... -
Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice
Espinosa Velasco, María; Reguilón, Marina D.; Bellot, Marina; Nadal Gratacós, Núria; Berzosa Rodríguez, Xavier; Gómez Canela, Cristian; Rodríguez Arias, Marta; Camarasa, Jordi; Fonseca, David; Pubill, David; López-Arnau, Raúl (Progress in Neuro-Psychopharmacology and Biological Psychiatry 2022, 117, 110562, 2022-07)N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into the illicit drug market. This drug has psychostimulant properties ... -
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
Duart-Castells, L.; Nadal Gratacós, Núria; Muralter, M.; Puster, B.; Berzosa Rodríguez, Xavier; Estrada Tejedor, Roger; Niello, M.; Bhat, S.; Pubill, David; Camarasa, Jordi; Sitte, H. H.; Fonseca, David; López-Arnau, Raúl (Neuropharmacology, 2021-03-15)The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present ... -
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
Puigseslloses, Pol; Nadal Gratacós, Núria; Ketsela, Gabriel; Weiss, Nicola; Berzosa Rodríguez, Xavier; Estrada Tejedor, Roger; Islam, Mohammad Nazmul; Holy, Marion; Niello, Marco; Pubill, David; Camarasa, Jordi; Escubedo, Elena; Sitte, Harald; López-Arnau, Raúl (Molecular Psychiatry. 2024;29:2346-2358, 2024-03-14)Recent studies have sparked renewed interest in the therapeutic potential of psychedelics for treating depression and other mental health conditions. Simultaneously, the novel psychoactive substances ... -
Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes
Nadal Gratacós, Núria; Alberto-Silva, Ana Sofia; Rodríguez-Soler, Míriam; Urquizu, Edurne; Espinosa-Velasco, Maria; Jäntsch, Kathrin; Holy, Marion; Batllori Aguilà, Xavier; Berzosa Rodríguez, Xavier; Pubill, David; Camarasa, Jordi; Sitte, Harald; Fonseca, David; López-Arnau, Raúl (Frontiers in Pharmacology 2021;12:749429, 2021-10-26)Several new synthetic cathinones, which mimic the effect of classical psychostimulants such as cocaine or MDMA, have appeared in the global illicit drug market in the last decades. In fact, the illicit ...