Browsing IQS by Author 

Browsing IQS by Author "Bosch, Manel"

Now showing items 1-5 of 5

    • A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions 

      Ortega Forte, Enrique; Rovira, Anna; López Corrales, Marta; Hernández García, Alba; Ballester, Francisco José; Izquierdo García, Eduardo; Jordà Redondo, Mireia; Bosch, Manel; Nonell, Santi; Santana, María Dolores; Ruiz, José; Marchán, Vicente; Gasser, Gilles (Chemical Space 2023, 15(26), 2023-07-14)
      Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) hampers its therapeutic efficacy, especially ...

    • Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(iii)–COUPY conjugates 

      Ortega-Forte, Enrique; Rovira, Anna; Ashoo, Pezhman; Izquierdo García, Eduardo; Hally, Cormac; Abad-Montero, Diego; Jordà Redondo, Mireia; Vigueras Bautista, Gloria; Deyà, Alba; Hernández, José Luis; GALINO, JORGE; Bosch, Manel; Alberto, Marta Erminia; Francés-Monerris, Antonio; Nonell, Santi; Ruiz, Jose; Marchán, Vicente (Inorganic Chemistry Frontiers 2023, 12 (9), 2025-05-07)
      Despite the potential of photodynamic therapy (PDT), this oxygen-dependent oncological treatment is greatly restricted in the clinic by the well-known hypoxic feature of solid tumors. Here we provide ...

    • Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates 

      Rovira, Anna; Ortega Forte, Enrique; Hally, Cormac; Jordà Redondo, Mireia; Abad-Montero, Diego; Vigueras, Gloria; Martínez, Jesús I.; Bosch, Manel; Nonell, Santi; Ruiz, José; Marchán, Vicente (Journal of Medicinal Chemistry 2023, 66 (12), 2023-06-22)
      Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under ...

    • High photostability in nonconventional coumarins with far-red/NIR emission through azetidinyl substitution 

      Nonell, Santi; Bresolí Obach, Roger; Gandioso, Albert; Palau Requena, Marta; Galindo Muñoz, Alex; Rovira, Anna; Bosch, Manel; Marchán Sancho, Vicente (Journal of Organic Chemistry. Vol.83, n.19 (2018), p.11519-11531, 2018-08)
      Replacement of electron-donating N,N-dialkyl groups with three- or four-membered cyclic amines (e.g., aziridine and azetidine, respectively) has been described as a promising approach to improve some ...

    • Mitochondria-Targeted COUPY Photocages: Synthesis and Visible-Light Photoactivation in Living Cells 

      López Corrales, Marta; Rovira, Anna; Gandioso, Albert; Nonell, Santi; Bosch, Manel; Marchán, Vicente (The Journal of Organic Chemistry 2023, 88, 7128-7140, 2023-06-02)
      Releasing bioactive molecules in specific subcellular locations from the corresponding caged precursors offers great potential in photopharmacology, especially when using biologically compatible visible ...