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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorNonell, Santi
dc.contributor.authorJuarranz, Ángeles
dc.contributor.authorDe la Torre, Gema
dc.contributor.authorTorres, Tomás
dc.contributor.authorRevuelta-Maza, Miguel Á.
dc.contributor.authorMascaraque, Marta
dc.contributor.authorGonzález-Jiménez, Patricia
dc.contributor.authorGonzález-Camuñas, Arturo
dc.date.accessioned2021-06-10T06:41:28Z
dc.date.accessioned2023-07-13T05:46:09Z
dc.date.available2021-06-10T06:41:28Z
dc.date.available2023-07-13T05:46:09Z
dc.date.issued2020-01
dc.identifier.urihttp://hdl.handle.net/20.500.14342/1124
dc.description.abstractWe have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., bis(trifluoromethyl)phenyl units) at facing positions of ABAB Zn(II)Pcs, where A and B refer to differently functionalized isoindoles. In this work, we have prepared the Zn(II)Pc ABAB 1 endowed with hydrophilic triethylene glycol monomethyl ether (i.e., at the A isoindoles) to provide solubility in aqueous media, together with its A3B and A4 counterparts, and compared their ability to behave as photosensitizers for photodynamic therapy. All photophysical data, aggregation studies and preliminary in vitro biological assays in cell cultures of SCC-13 (squamous cell carcinoma) and HeLa (cervical cancer cells), have proved ABAB 1 as the best photosensitizer of the series.eng
dc.format.extent18 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofMolecules. Vol.25, n.1 (2020), 213cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherFotosensibilització (Biologia)cat
dc.subject.otherZn(II) phthalocyaninescat
dc.subject.otherABABcat
dc.subject.otherAmphiphiliccat
dc.subject.otherPhotodynamic therapycat
dc.subject.otherHeLacat
dc.subject.otherSCC-13cat
dc.titleAssessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancercat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc577
dc.identifier.doihttps://doi.org/10.3390/molecules25010213cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-Rcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO i FEDER/PN I+D/FIS PI18/00708cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/ERA-NET i MINECO/EuroNanoMed2017-191/PCIN-2017-042cat


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