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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorNonell, Santi
dc.contributor.authorPlanas, Oriol
dc.contributor.authorGallavardin, Thibault
dc.contributor.authorNieves, Ingrid
dc.contributor.authorTabero, Andrea
dc.contributor.authorVillanueva, Ángeles
dc.date.accessioned2022-03-07T12:45:48Z
dc.date.accessioned2023-07-13T05:45:06Z
dc.date.available2022-03-07T12:45:48Z
dc.date.available2023-07-13T05:45:06Z
dc.date.issued2020-12
dc.identifier.urihttp://hdl.handle.net/20.500.14342/1071
dc.description.abstractWe report the preparation of gold nanoclusters (AuNCs) as a delivery vehicle for the clinically approved photodynamic and chemotherapeutic agents Protoporphyrin IX (PpIX) and doxorubicin (DOX), respectively, and their effect on tumor cells. DOX was attached to the gold nanoclusters through a singlet oxygen-cleavable linker and was therefore released after PpIX irradiation with red light, contributing, synergistically with singlet oxygen, to induce cell death. The doubly functionalized AuNCs proved more effective than a combination of individually functionalized AuNCs. Unlike free DOX, the photoactive nanosystem was non-toxic in the absence of light, which paves the way to introduce a spatiotemporal control of the anticancer therapy and could contribute to reducing the undesirable side effects of DOX.eng
dc.format.extent15 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofNanomaterials. Vol.10, n.12 (2020), 2474cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherFotoquimioteràpiacat
dc.subject.otherFototeràpiacat
dc.subject.otherNanoquímicacat
dc.subject.otherPhotodynamic therapycat
dc.subject.otherChemophototherapycat
dc.subject.otherGold nanoclusterscat
dc.subject.otherPhotonanomedicinecat
dc.subject.otherDoxorubicincat
dc.subject.otherProtoporphyrin IXcat
dc.titleSmart dual-functionalized gold nanoclusters for spatio-temporally controlled delivery of combined chemo- and photodynamic therapycat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc539
dc.subject.udc543
dc.identifier.doihttps://doi.org/10.3390/nano10122474cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-2-Rcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-Rcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/Comunidad de Madrid/S2018/NMT-4321 NANOMAGCOST-CMcat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Severo Ochoa Programme for Centers of Excellence in R&D/SEV-2016-0686cat


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Attribution 4.0 International
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