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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorNonell, Santi
dc.contributor.authorAgut Bonsfills, Montserrat
dc.contributor.authorBresolí-Obach, Roger
dc.contributor.authorFrattini, Marcello
dc.contributor.authorAbbruzzetti, Stefania
dc.contributor.authorViappiani, Cristiano
dc.date.accessioned2022-03-07T13:01:28Z
dc.date.accessioned2023-07-13T05:45:03Z
dc.date.available2022-03-07T13:01:28Z
dc.date.available2023-07-13T05:45:03Z
dc.date.issued2020-10
dc.identifier.urihttp://hdl.handle.net/20.500.14342/1069
dc.description.abstractPhotoacoustic imaging is attracting a great deal of interest owing to its distinct advantages over other imaging techniques such as fluorescence or magnetic resonance image. The availability of photoacoustic probes for reactive oxygen and nitrogen species (ROS/RNS) could shed light on a plethora of biological processes mediated by these key intermediates. Tetramethylbenzidine (TMB) is a non-toxic and non-mutagenic colorless dye that develops a distinctive blue color upon oxidation. In this work, we have investigated the potential of TMB as an acoustogenic photoacoustic probe for ROS/RNS. Our results indicate that TMB reacts with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce the blue oxidation product, while ROS, such as the superoxide radical anion, sodium peroxide, hydroxyl radical, or peroxynitrite, yield a colorless oxidation product. TMB does not penetrate the Escherichia coli cytoplasm but is capable of detecting singlet oxygen generated in its outer membrane.eng
dc.format.extent16 p.cat
dc.language.isoengcat
dc.publisherMDPIcat
dc.relation.ispartofSensors. Vol.20, n.20 (2020), 5952cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherOxigen--Propietats acústiquescat
dc.subject.otherNitrogen--Propietats acústiquescat
dc.subject.other3,30,5,50-tetramethylbenzidinecat
dc.subject.otherReactive oxygen species (ROS)cat
dc.subject.otherReactive nitrogen species (RNS)cat
dc.subject.otherPhotoacoustic probescat
dc.subject.otherOptical sensorscat
dc.subject.otherSinglet oxygencat
dc.titleTetramethylbenzidine: an acoustogenic photoacoustic probe for reactive oxygen species detectioncat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc531/534
dc.identifier.doihttps://doi.org/10.3390/s20205952cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-Rcat
dc.relation.projectIDinfo: eu-repo/grantAgreement/SUR del DEC i FSE/FI/2017 FI_B2 00140cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/FWO/Grant 12Z8120Ncat


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