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dc.contributorUniversitat Ramon Llull. IQS
dc.contributor.authorBorrós i Gómez, Salvador
dc.contributor.authorCabanach, Pol
dc.contributor.authorPena-Francesch, Abdon
dc.contributor.authorSheehan, Devin
dc.contributor.authorBozuyuk, Ugur
dc.contributor.authorYasa, Oncay
dc.contributor.authorSitti, Metin
dc.date.accessioned2022-03-07T16:32:26Z
dc.date.accessioned2023-07-13T05:44:02Z
dc.date.available2022-03-07T16:32:26Z
dc.date.available2023-07-13T05:44:02Z
dc.date.issued2020-08
dc.identifier.urihttp://hdl.handle.net/20.500.14342/1014
dc.description.abstractMicrorobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non-immunogenic stealth zwitterionic microrobots that avoid recognition from immune cells are introduced. Fully zwitterionic photoresists are developed for two-photon polymerization 3D microprinting of hydrogel microrobots with ample functionalization: tunable mechanical properties, anti-biofouling and non-immunogenic properties, functionalization for magnetic actuation, encapsulation of biomolecules, and surface functionalization for drug delivery. Stealth microrobots avoid detection by macrophage cells of the innate immune system after exhaustive inspection (>90 hours), which has not been achieved in any microrobotic platform to date. These versatile zwitterionic materials eliminate a major roadblock in the development of biocompatible microrobots, and will serve as a toolbox of non-immunogenic materials for medical microrobot and other device technologies for bioengineering and biomedical applications.eng
dc.format.extent11 p.cat
dc.language.isoengcat
dc.publisherWileycat
dc.relation.ispartofAdvanced Materials. Vol.32, n.42 (2020), 2003013cat
dc.rightsAttribution 4.0 International
dc.rights© L'autor/a
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceRECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.otherMacròfagscat
dc.subject.otherImmunogenèticacat
dc.subject.otherMicrorobotscat
dc.subject.otherPolimeritzaciócat
dc.subject.otherMacrophagescat
dc.subject.otherNon-immunogenic propertiescat
dc.subject.otherStealth microrobotscat
dc.subject.otherTwophoton polymerizationcat
dc.subject.otherZwitterionic materialscat
dc.titleZwitterionic 3D-printed non-immunogenic stealth microrobotscat
dc.typeinfo:eu-repo/semantics/articlecat
dc.typeinfo:eu-repo/semantics/publishedVersioncat
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapcat
dc.subject.udc575
dc.subject.udc616
dc.identifier.doihttps://doi.org/10.1002/adma.202003013cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/MCIU/PN I+D/RTI2018-094734-B-C22cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC/SGR/SGR 2017 1559cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/ERC/Advanced Grant/Grant No:834531cat
dc.relation.projectIDinfo:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2019 FI_B2 00165cat


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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