Listando Recerca por materia "Base recognition"
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Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1
(Computational and Structural Biotechnology Journal, 2020-11-28)Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity ...