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Pharmacological modulation of behaviour, serotonin and dopamine levels in daphnia magna exposed to the monoamine oxidase inhibitor deprenyl
(Toxics, 2021-08-09)This study assessed the effects of the monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms of action of deprenyl were also determined by studying the relationship ... -
Pharmacological modulation of serotonin levels in zebrafish larvae: lessons for identifying environmental neurotoxicants targeting the serotonergic system
(Toxics, 2021-05-25)This study examines the effects of acute pharmacological modulation of the serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput ... -
Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas
(Afinidad. Vol.59, n.500 (2002), p.343-356, 2002)La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ... -
Prevalence study of intermittent hormonal therapy of prostate cancer patients in Spain [version 2; peer review: 2 approved]
(F1000Research, 2022, 10:1069, 2023-11)Background: Although intermittent androgen deprivation therapy was introduced many years ago to improve patients’ quality of life with the same carcinologic efficiency as continuous hormonal therapy, ... -
Profile of osteopathic practice in Spain: results from a standardized data collection study
(BMC Complementary and Alternative Medicine, 2018, 18:129, 2018-04)Background There is limited research regarding patients’ profiles and consumer attitudes and habits of osteopathy in Spain. The purpose of this study was to profile patients who regularly receive ... -
Programa de coordinación en la transición asistencial para la mejora de la farmacoterapia entre un Servicio de Urgencias y un Centro Sociosanitario
(Revista de la OFIL = ILAPHAR, 2022, vol. 32, núm. 2, p. 163-166, 2022)Objetivos: Describir un programa de colaboración entre farmacéuticos de un Servicio de Urgencias y un Centro sociosanitario, así como evaluar su impacto sobre la frecuencia de reconsulta al Servicio de ... -
Realitats, paradoxes i posicionaments sobre drogues
(Aloma, 2002, Núm. 10, 2002) -
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
(Neuropharmacology, 2021-03-15)The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present ... -
Role of Survivin in Bladder Cancer: Issues to Be Overcome When Designing an Efficient Dual Nano-Therapy
(Pharmaceutics, 2021-11-19)Bladder cancer is the 10th most diagnosed cancer, with almost 10 M cancer deaths last year worldwide. Currently, chemotherapy is widely used as adjuvant therapy after surgical transurethral resection. ... -
Structural implications of the DFD-in domain in computer-aided molecular design of MAP kinase interacting kinase 2 inhibitors
(Afinidad. Vol.74, n.578 (2017), p.83-89, 2017-04)Protein translation is a key process on cell development and proliferation that is often deregulated in cancer. MAP kinase interacting kinases 1 and 2 (Mnk1/2) play a pivotal role in regulating the ... -
The Impact of pharmaceutical care in multidisciplinary teams on health outcomes: systematic review and meta-analysis
(Journal of the American Medical Directors Association (JAMDA), 2021, vol. 22, núm. 12, p. 2518-2526, 2021-07)Objectives Pharmacists’ care has an essential role in multidisciplinary teams in charge of chronic patients. However, data available on the clinical outcomes of these activities appear inconclusive. ... -
Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish
(Scientific Reports. Vol.9, n.1 (2019), 16467, 2019-11)Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and ... -
Two-component systems of mycobacterium tuberculosis as potential targets for drug development
(Afinidad. Vol.71, n.567 (2014), p.172-178, 2014-07)Tuberculosis, caused by Mycobacterium tuberculosis, is a global health problem with approximately two million deaths every year. Furthermore, up to one-third of the world population is infected with ... -
Validity and reliability of the satel 40 Hz stabilometric force platform for measuring quiet stance and dynamic standing balance in healthy subjects
(International Journal on Environmental Research and Public Health, 2020, 17(21), 7733, 2020-10-22)Background: A force platform must have validity and reliability for optimal use. The objective of this study was to analyze the validity and the reliability of the Satel 40 Hz stabilometric force ... -
Whole body vibration for older persons: an open randomized, multicentre, parallel, clinical trial
(BMC Geriatrics, 2011, vol. 11, núm. 89, 2011-12)Background Institutionalized older persons have a poor functional capacity. Including physical exercise in their routine activities decreases their frailty and improves their quality of life. Whole-body ... -
Zwitterionic self-assembled nanoparticles as carriers for Plasmodium targeting in malaria oral treatment
(Journal of Controlled Release. Vol.331, p.364-375, 2021-03-10)The current decline in antimalarial drug efficacy due to the evolution of resistant Plasmodium strains calls for new strategies capable of improving the bioavailability of antimalarials, especially of ...