Browsing Recerca by Author "Faria, Melissa"
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A Zebrafish Model of Neurotoxicity by Binge-Like Methamphetamine Exposure
Bedrossiantz, Juliette; Bellot, Marina; Domínguez García, Pol; Faria, Melissa; Prats, Eva; Gómez-Canela, Cristian; López-Arnau, Raúl; Fonseca, David; Raldúa, Demetrio (Frontiers in Pharmacology, 2021-11-22)Hyperthermia is a common confounding factor for assessing the neurotoxic effects of methamphetamine (METH) in mammalian models. The development of new models of methamphetamine neurotoxicity using ... -
Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion
Faria, Melissa; Prats, Eva; Rosas Ramírez, Jonathan Ricardo; Bellot, Marina; Bedrossiantz, Juliette; Pagano, Maria; Valls, Arnau; Gómez-Canela, Cristian; Porta, Josep M; Mestres, Jordi; Garcia-Reyero, Natàlia; Faggio, Caterina; Gómez-Oliván, Leobardo Manuel; Raldúa, Demetrio (Science of the Total Environment, 2021-06-25)Fenitrothion is an organophosphorus insecticide usually found in aquatic ecosystems at concentrations in the range of low ng/L. In this manuscript we show that 24 h exposure to environmental concentrations ... -
Differential modulation of the central and peripheral monoaminergic neurochemicals by deprenyl in Zebrafish Larvae
Bellot, Marina; Bartolomé, Helena; Faria, Melissa; Gómez-Canela, Cristian; Raldúa, Demetrio (Toxics, 2021-05-23)Zebrafish embryos and larvae are vertebrate models increasingly used in translational neuroscience research. Behavioral impairment induced by the exposure to neuroactive or neurotoxic compounds is ... -
Environmental levels of carbaryl impair zebrafish larvae behaviour: The potential role of ADRA2B and HTR2B
Faria, Melissa; Bellot, Marina; Bedrossiantz, Juliette; Rosas Ramírez, Jonathan Ricardo; Prats, Eva; Garcia-Reyero, Natàlia; Gómez-Canela, Cristian; Mestres, Jordi; Rovira, Xavier; Barata, Carlos; Gómez-Oliván, Leobardo Manuel; Llebaria, Amadeu; Raldúa, Demetrio (Journal of Hazardous Materials Volume 2022, 431,128563, 2022)The insecticide carbaryl is commonly found in indirectly exposed freshwater ecosystems at low concentrations considered safe for fish communities. In this study, we showed that after only 24 h of exposure ... -
Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety
Faria, Melissa; Bedrossiantz, Juliette; Rosas Ramírez, Jonathan Ricardo; Mayol, Marta; Heredia García, Gerardo; Bellot, Marina; Prats, Eva; Garcia-Reyero, Natàlia; Gómez-Canela, Cristian; Gómez-Oliván, Leobardo Manuel; Raldúa, Demetrio (Environment International, 2020-11-18)Glyphosate is the active ingredient of some of the most highly produced and used herbicides worldwide. The intensive applications of glyphosate-based herbicides and its half-life in water lead to its ... -
Impact of environmentally relevant concentrations of fluoxetine on zebrafish larvae: From gene to behavior
Correia, Daniela; Bellot, Marina; Prats, Eva; Gómez-Canela, Cristian; Moro, Hugo; Raldúa, Demetrio; Domingues, Ines; Oliveira, Miguel; Faria, Melissa (Chemosphere 2023, 345, 2023-12)Fluoxetine is widely prescribed for the treatment of depressive states, acting at the level of the central nervous system, consequently affecting non-target organisms. This study aimed to investigate ... -
Parental exposure to antidepressants has lasting effects on offspring? A case study with zebrafish
Correia, Daniela; Bellot, Marina; Goyenechea, Júlia; Prats, Eva; Moro, Hugo; Gómez-Canela, Cristian; Bedrossiantz, Juliette; Tagkalidou, Niki; Ferreira, Carla S.S.; Raldúa, Demetrio; Domingues, Inês; Faria, Melissa; Oliveira, Miguel (Chemosphere. 2024;355:141851, 2024-04-09)Fish have common neurotransmitter pathways with humans, exhibiting a significant degree of conservation and homology. Thus, exposure to fluoxetine makes fish potentially susceptible to biochemical and ... -
Pharmacological modulation of behaviour, serotonin and dopamine levels in daphnia magna exposed to the monoamine oxidase inhibitor deprenyl
Bellot, Marina; Faria, Melissa; Gómez-Canela, Cristian; Raldúa, Demetrio; Barata, Carlos (Toxics, 2021-08-09)This study assessed the effects of the monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms of action of deprenyl were also determined by studying the relationship ... -
Pharmacological modulation of serotonin levels in zebrafish larvae: lessons for identifying environmental neurotoxicants targeting the serotonergic system
Faria, Melissa; Prats, Eva; Bellot, Marina; Gómez-Canela, Cristian; Raldúa, Demetrio (Toxics, 2021-05-25)This study examines the effects of acute pharmacological modulation of the serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput ... -
Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish
Gómez-Canela, Cristian; Faria, Melissa; Prats, Eva; Hsu, Chuan-Yu; Arick, Mark A. II; Bedrossiantz, Juliette; Orozco, Manuel; Garcia-Reyero, Natàlia; Ziv, Tamar; Ben-Lulu, Shani; Admon, Arie; Gómez-Oliván, Leobardo Manuel; Raldúa, Demetrio (Scientific Reports. Vol.9, n.1 (2019), 16467, 2019-11)Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and ...