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Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion
Faria, Melissa; Prats, Eva; Rosas Ramírez, Jonathan Ricardo; Bellot, Marina; Bedrossiantz, Juliette; Pagano, Maria; Valls, Arnau; Gómez Canela, Cristian; Porta, Josep M; Mestres, Jordi; Garcia-Reyero, Natàlia; Faggio, Caterina; Gómez-Oliván, Leobardo Manuel; Raldua, Demetrio (Science of the Total Environment, 2021-06-25)Fenitrothion is an organophosphorus insecticide usually found in aquatic ecosystems at concentrations in the range of low ng/L. In this manuscript we show that 24 h exposure to environmental concentrations ... -
Differential modulation of the central and peripheral monoaminergic neurochemicals by deprenyl in Zebrafish Larvae
Bellot, Marina; Bartolomé, Helena; Faria, Melissa; Gómez Canela, Cristian; Raldúa, Demetrio (Toxics, 2021-05-23)Zebrafish embryos and larvae are vertebrate models increasingly used in translational neuroscience research. Behavioral impairment induced by the exposure to neuroactive or neurotoxic compounds is ... -
Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety
Faria, Melissa; Bedrossiantz, Juliette; Rosas Ramírez, Jonathan Ricardo; Mayol, Marta; Heredia García, Gerardo; Bellot, Marina; Prats, Eva; Garcia-Reyero, Natàlia; Gómez Canela, Cristian; Gómez-Oliván, Leobardo Manuel; Raldua, Demetrio (Environment International, 2020-11-18)Glyphosate is the active ingredient of some of the most highly produced and used herbicides worldwide. The intensive applications of glyphosate-based herbicides and its half-life in water lead to its ... -
Pharmacological modulation of behaviour, serotonin and dopamine levels in daphnia magna exposed to the monoamine oxidase inhibitor deprenyl
Bellot, Marina; Faria, Melissa; Gómez Canela, Cristian; Raldúa, Demetrio; Barata, Carlos (Toxics, 2021-08-09)This study assessed the effects of the monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms of action of deprenyl were also determined by studying the relationship ... -
Pharmacological modulation of serotonin levels in zebrafish larvae: lessons for identifying environmental neurotoxicants targeting the serotonergic system
Faria, Melissa; Prats, Eva; Bellot, Marina; Gómez Canela, Cristian; Raldúa, Demetrio (Toxics, 2021-05-25)This study examines the effects of acute pharmacological modulation of the serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput ... -
Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish
Gómez Canela, Cristian; Faria, Melissa; Prats, Eva; Hsu, Chuan-Yu; Arick, Mark A. II; Bedrossiantz, Juliette; Orozco, Manuel; Garcia-Reyero, Natàlia; Ziv, Tamar; Ben-Lulu, Shani; Admon, Arie; Gómez-Oliván, Leonardo Manuel; Raldúa, Demetrio (Scientific Reports. Vol.9, n.1 (2019), 16467, 2019-11)Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and ...