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Browsing by Subject "biological activity"

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    • 1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications 

      Oliveras, Juan Marcos; Puig de la Bellacasa Cazorla, Raimon; Estrada Tejedor, Roger; Teixidó i Closa, Jordi; Borrell Bilbao, José Ignacio (Pharmaceuticals 2021;14(10):1029, 2021-10-09)
      Naphthyridines, also known as diazanaphthalenes, are a group of heterocyclic compounds that include six isomeric bicyclic systems containing two pyridine rings. 1,6-Naphthyridines are one of the members ...

    • When Unsuspected Crystallinity Ruins Biological Testing in Early Discovery: A Case Study 

      de Rocafiguera, Claudi; Belsa, Blanca; Font-Bardia, Mercè; Puigjaner, Cristina; Serra Hosta, Eduard; Cuartero Albesa, Ana María; Puig de la Bellacasa Cazorla, Raimon; Borrell Bilbao, José Ignacio (Pharmaceuticals. 2024;17(3):284, 2024-02-22)
      The impact of the crystalline or amorphous structure of a solid on the solubility and pharmacokinetic properties of a drug candidate is always considered by the pharmaceutical industry during the ...