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Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus
(Journal of clinical medicine, 2020, vol. 10, núm. 1, 85, 2020-12-29)We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based ... -
Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
(The Lancet Regional Health Europe, 2023, 35: 100771, 2023-12)Background It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption ... -
Efectos de la musicoterapia como técnica terapéutica a distancia en pacientes oncológicos. Ensayo piloto con un modelo de música de carácter relajante
(Aloma, 2021, Vol. 39, Núm. 2, 2021)Se conocen poco los efectos terapéuticos que tiene en el estado de ánimo escuchar música con finalidad terapéutica, en pacientes con cáncer. Se presenta un estudio piloto sobre musicoterapia en el que ... -
Engineered microtissues for the bystander therapy against cancer
(Materials Science and Engineering C, 2021-01-13)Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this ... -
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles for the co-delivery of DOX/CPT-PEG for targeting HepG2 cells
(Pharmaceutics. Vol.12, n.11 (2020), 1048, 2020-11)A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles ... -
Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study
(PLoS Medicine, 2018, 15(9): e1002651, 2018-09)Background Helping consumers make healthier food choices is a key issue for the prevention of cancer and other diseases. In many countries, political authorities are considering the implementation of ... -
Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas
(Afinidad. Vol.59, n.500 (2002), p.343-356, 2002)La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ... -
Recent advances in the pharmacological targeting of ubiquitin-regulating enzymes in cancer
(Seminars in Cell & Developmental Biology 2022, 132, 213-229, 2022-12)As a post-translational modification that has pivotal roles in protein degradation, ubiquitination ensures that intracellular proteins act in a precise spatial and temporal manner to regulate diversified ... -
Structural implications of the DFD-in domain in computer-aided molecular design of MAP kinase interacting kinase 2 inhibitors
(Afinidad. Vol.74, n.578 (2017), p.83-89, 2017-04)Protein translation is a key process on cell development and proliferation that is often deregulated in cancer. MAP kinase interacting kinases 1 and 2 (Mnk1/2) play a pivotal role in regulating the ... -
Three-dimensional tumor-stroma co-culture system development using self-assembling peptide scaffolds
(Afinidad. Vol.76, n.587 (2019), p.163-170, 2019-07)Cancer research has traditionally relied on 2D cell culture, focusing mainly on cancer cells and its disrupted genetics. However, tumors have been accepted as complex tissues, and as such, they need ...