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Browsing by Subject "Sistema nerviós--Degeneració"

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    • Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type 

      Carus Cadavieco, Marta; Berenguer López, Inés; Montoro Canelo, Alba; Serrano Lope, Miguel A; González de la Fuente, Sandra; Aguado, Begoña; Fernández Rodrigo, Alba; Saido, Takaomi C; Frank García, Ana; Venero, César; Esteban, José A; Guix Rafols, Francesc Xavier; Dotti, Carlos G (Life Science Alliance 2023, 6 (6), e202201789, 2023-06)
      In this work, we tested the hypothesis that the development of dementia in individuals with type 2 diabetes (T2DM) requires a genetic background of predisposition to neurodegenerative disease. As a proof ...

    • Malin restoration as proof of concept for gene therapy for Lafora disease 

      Varea, Olga; Guinovart, Joan; Duran Castells, Jordi (Brain Communications 2022, 4(4), fcac168, 2022)
      Lafora disease is a fatal neurodegenerative childhood dementia caused by loss-of-function mutations in either the laforin or malin gene. The hallmark of the disease is the accumulation of abnormal ...