Now showing items 1-8 of 8

    • A machine learning approach to predict cellular uptake of pBAE polyplexes 

      Loecher, Aparna; Bruyns-Haylett, Michael; Ballester, Pedro J.; Borrós i Gómez, Salvador; Oliva, Núria (Biomaterials Science 2023, 12(17), 5697-6002, 2023-09)
      The delivery of genetic material (DNA and RNA) to cells can cure a wide range of diseases but is limited by the delivery efficiency of the carrier system. Poly β-amino esters (pBAEs) are promising ...
    • Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy 

      Riera, Roger; Tauler, Jana; Feiner Gracia, Natàlia; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina; Albertazzi, Lorenzo (ChemMedChem 2022, 17(13), e202100633, 2022)
      Nanomedicine emerged some decades ago with the hope to be the solution for most unmet medical needs. However, tracking materials at nanoscale is challenging to their reduced size, below the resolution ...
    • Detection of peptide-based nanoparticles in blood plasma by ELISA 

      Borrós i Gómez, Salvador; Bode, Gerard H.; Pickl, Karin E.; Sánchez Purrà, Maria; Albaiges, Berta; Pötgens, Andy J. G.; Schmitz, Christoph; Sinner, Frank M.; Losen, Mario; Steinbusch, Harry W. M.; Frank, Hans-Georg; Martinez-Martinez, Pilar (PLoS ONE. Vol.10, n.5 (2015), e0126136, 2015-05)
      Aims The aim of the current study was to develop a method to detect peptide-linked nanoparticles in blood plasma. Materials & Methods A convenient enzyme linked immunosorbent assay (ELISA) was developed ...
    • Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells 

      Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Salinas, Yolanda; Kneidinger, Michael; Bruggemann, Oliver; Teasdale, Ian (RSC Advances. Vol.10, n.46 (2020), p.27305-27314, 2020-07)
      A switchable silane derived stimuli-responsive bottle-brush polyphosphazene (PPz) was prepared and attached to the surface of mesoporous silica nanoparticles (MSNs). The hybrid polymer with PEG-like ...
    • Extracellular vesicles and their current role in cancer immunotherapy 

      Giacobino, Carla; Canta, Marta; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Cauda, Valentina (Cancers, 2021-05-10)
      Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ...
    • Nanostructured AABB Zn (II) Phthalocyanines as Photodynamic Agents for Bacterial Inactivation 

      Paramio, Irene; Salazar, Ainhoa; Jordà Redondo, Mireia; Nonell, Santi; Torres, Tomás; De la Torre, Gema (Advanced Therapeutics 2023, 6 (11), 2300116, 2023-11)
      In this work, the ability of amphiphilic Phthalocyanine (Pc) photosensitizers (PS) (Zn(II)Pcs PS1, PS2, and PS3) to assemble into cationic nanoparticles in water and to photo-inactivate bacterial strains ...
    • Preparation and applications of organo-silica hybrid mesoporous silica nanoparticles for the co-delivery of drugs and nucleic acids 

      Sánchez García, David; Pontón, Iris; Martí del Rio, Andrea; Gómez Gómez, Marta (Nanomaterials. Vol.10, n.12 (2020), 2466, 2020-12)
      Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the ...
    • The primeval optical evolving matter by optical binding inside and outside the photon beam 

      Huang, Chih-Hao; Louis, Boris; Bresolí Obach, Roger; Kudo, Tetsuhiro; Camacho, Rafael; Scheblykin, Ivan; Sugiyama, Teruki; Hofkens, Johan; Masuhara, Hiroshi (Nature Communications 2022, 13(1), 5325, 2022)
      Optical binding has recently gained considerable attention because it enables the light-induced assembly of many-body systems; however, this phenomenon has only been described between directly irradiated ...