Browsing by Subject "Nanopartícules"
Now showing items 1-16 of 16
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A machine learning approach to predict cellular uptake of pBAE polyplexes
(Biomaterials Science 2023, 12(17), 5697-6002, 2023-09)The delivery of genetic material (DNA and RNA) to cells can cure a wide range of diseases but is limited by the delivery efficiency of the carrier system. Poly β-amino esters (pBAEs) are promising ... -
Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas
(Drug Delivery, 2018-02-07)Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, ... -
Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy
(ChemMedChem 2022, 17(13), e202100633, 2022)Nanomedicine emerged some decades ago with the hope to be the solution for most unmet medical needs. However, tracking materials at nanoscale is challenging to their reduced size, below the resolution ... -
Detection of peptide-based nanoparticles in blood plasma by ELISA
(PLoS ONE. Vol.10, n.5 (2015), e0126136, 2015-05)Aims The aim of the current study was to develop a method to detect peptide-linked nanoparticles in blood plasma. Materials & Methods A convenient enzyme linked immunosorbent assay (ELISA) was developed ... -
Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells
(RSC Advances. Vol.10, n.46 (2020), p.27305-27314, 2020-07)A switchable silane derived stimuli-responsive bottle-brush polyphosphazene (PPz) was prepared and attached to the surface of mesoporous silica nanoparticles (MSNs). The hybrid polymer with PEG-like ... -
Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection
(Journal of Neuromuscular Diseases, vol. 8, no. 5, pp. 815-825, 2021-09-14)Background:Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. ... -
Extracellular vesicles and their current role in cancer immunotherapy
(Cancers, 2021-05-10)Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ... -
Fine-tuning formulation and biological interaction of doxorubicin-loaded polymeric nanoparticles via electrolyte concentration modulation
(Journal of Molecular Liquids, 2023, vol. 390, part A, 122986, 2023-09)Doxorubicin (DOX) is amongst the most widely used chemotherapeutic drugs against various cancers. However, its controlled biodistribution to the tumor site at the required pharmacokinetics profile ... -
Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles
(Advanced Science 2025, 12 (16), 2025-04-24)Macrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer-promoting activity or trigger anti-inflammatory ... -
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles for the co-delivery of DOX/CPT-PEG for targeting HepG2 cells
(Pharmaceutics. Vol.12, n.11 (2020), 1048, 2020-11)A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles ... -
Nanostructured AABB Zn (II) Phthalocyanines as Photodynamic Agents for Bacterial Inactivation
(Advanced Therapeutics 2023, 6 (11), 2300116, 2023-11)In this work, the ability of amphiphilic Phthalocyanine (Pc) photosensitizers (PS) (Zn(II)Pcs PS1, PS2, and PS3) to assemble into cationic nanoparticles in water and to photo-inactivate bacterial strains ... -
PEI-mediated transient transfection of high five cells at bioreactor scale for HIV-1 VLP production
(Nanomaterials. Vol.10, n.8 (2020), 1580, 2020-08)High Five cells are an excellent host for the production of virus-like particles (VLPs) with the baculovirus expression vector system (BEVS). However, the concurrent production of high titers of baculovirus ... -
Preparation and applications of organo-silica hybrid mesoporous silica nanoparticles for the co-delivery of drugs and nucleic acids
(Nanomaterials. Vol.10, n.12 (2020), 2466, 2020-12)Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the ... -
Safety of nanoparticle therapies during pregnancy: A systematic review and meta-analysis
(Journal of Controlled Release, 2025, 382: 113655, 2025-06)The exclusion of pregnant women from clinical trials has led to insufficient safety data for many treatments, making it necessary to evaluate their potential benefits and risks during preclinical stages. ... -
Simple generation of human induced pluripotent stem cells using poly-β-amino esters as the non-viral gene delivery system
(Journal of Biological Chemistry. Vol.286,n.14 (2011),p.12417-12428, 2011-04)Reprogramming of somatic cells to induced pluripotent stem (iPS) cells can be achieved by the delivery of a combination of transcription factors, including Oct4, Sox2, Klf4, and c-Myc. Retroviral and ... -
The primeval optical evolving matter by optical binding inside and outside the photon beam
(Nature Communications 2022, 13(1), 5325, 2022)Optical binding has recently gained considerable attention because it enables the light-induced assembly of many-body systems; however, this phenomenon has only been described between directly irradiated ...