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Browsing by Subject "Myotonic dystrophy"

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    • Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1 

      Ondono, Raul; Lirio, Ángel; Carlos, Elvira; Álvarez-Marimon, Elena; Provenzano, Claudia; Cardinali, Beatrice; Pérez-Alonso, Manuel; Perálvarez-Marín, Alex; Borrell Bilbao, José Ignacio; Falcone, Germana; Estrada Tejedor, Roger (Computational and Structural Biotechnology Journal, 2020-11-28)
      Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity ...

    • In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models 

      Estrada Tejedor, Roger; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; González, Àlex L.; Konieczn, Piotr; Llamusi, Beatriz; Delgado-Pinar, Estefanía; Garcia-España, Enrique; Pérez-Alonso, Manuel; Artero, Ruben (PLoS ONE. Vol.12, n.6 (2017), e0178931, 2017-06)
      Myotonic dystrophy type 1 (DM1) is a rare multisystemic disorder associated with an expansion of CUG repeats in mutant DMPK (dystrophia myotonica protein kinase) transcripts; the main effect of these ...