Browsing by Subject "Medicaments--Desenvolupament"
Now showing items 1-3 of 3
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De-Novo Design of pre-miR-21 Maturation Inhibitors: Synthesis and Activity Assessment
(Chemistry - A European Journal 2023, 29(40),e202300825, 2023-07-14)Targeting RNA with small molecules is a major challenge of current medicinal chemistry, and the identification and design of original scaffolds able to selectively interact with an RNA target remains ... -
Deconstructing Markush: Improving the R&D Efficiency Using Library Selection in Early Drug Discovery
(Pharmaceuticals 2022, 15(9), 1159, 2022)Most of the product patents claim a large number of compounds based on a Markush structure. However, the identification and optimization of new principal active ingredients is frequently driven by a ... -
Two-component systems of mycobacterium tuberculosis as potential targets for drug development
(Afinidad. Vol.71, n.567 (2014), p.172-178, 2014-07)Tuberculosis, caused by Mycobacterium tuberculosis, is a global health problem with approximately two million deaths every year. Furthermore, up to one-third of the world population is infected with ...