Browsing by Subject "Glicogen"
Now showing items 1-5 of 5
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Active Glycogen Synthase in the Liver Prevents High-Fat Diet-Induced Glucose Intolerance, Decreases Food Intake, and Lowers Body Weight
(International Journal of Molecular Sciences 2023, 24(13), 2574, 2023-02)Many lines of evidence demonstrate a correlation between liver glycogen content and food intake. We previously demonstrated that mice overexpressing protein targeting to glycogen (PTG) specifically in ... -
Glycogenin is dispensable for normal liver glycogen metabolism and body glucose homeostasis
(International Journal of Biological Macromolecules 2025, 291, 139084, 2025-02)Glycogen is a glucose-storage polysaccharide molecule present in animals, fungi and bacteria. The enzyme glycogenin can self-glycosylate, forming an oligosaccharide chain that primes glycogen synthesis. ... -
Hepatic overexpression of protein targeting to glycogen attenuates obesity and improves hyperglycemia in db/db mice
(Frontiers in Endocrinology, 2022, 13, 969924, 2022)Increased liver glycogen content has been shown to reduce food intake, attenuate obesity, and improve glucose tolerance in a mouse model of high-fat diet (HFD)-induced obesity. Here we studied the ... -
Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora
(Molecular Neurobiology 2022, 59, 1214-1229, 2022)Lafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates—the so-called Lafora Bodies (LBs)—in several organs. The accumulation of LBs ... -
Malin restoration as proof of concept for gene therapy for Lafora disease
(Brain Communications 2022, 4(4), fcac168, 2022)Lafora disease is a fatal neurodegenerative childhood dementia caused by loss-of-function mutations in either the laforin or malin gene. The hallmark of the disease is the accumulation of abnormal ...