Browsing by Subject "Computational screening"

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Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease

Planas, Antoni (Planas Sauter); Cotrina, Ellen Y.; Santos, Luis Miguel; Rivas, Josep; Blasi, Daniel; Leite, José Pedro; Liz, Márcia A.; Busquets, Maria Antònia; Prohens, Rafel; Gimeno, Ana; Jiménez-Barbero, Jesús; Gales, Luis; Llop, Jordi; Quintana, Jordi; Cardoso, Isabel; Arsequell, Gemma (European Journal of Medicinal Chemistry, 2021-12-15)

Transthyretin (TTR) has a well-established role in neuroprotection in Alzheimer's Disease (AD). We have setup a drug discovery program of small-molecule compounds that act as chaperones enhancing ...