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Browsing by Subject "Còlon -- Càncer"

Now showing items 1-7 of 7

    • Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Harewood, Rhea; Rothwell, Joseph A.; Bešević, Jelena; Viallon, Vivian; Achaintre, David; Gicquiau, Audrey; Rinaldi, Sabina; Wedekind, Roland; Prehn, Cornelia; Adamski, Jerzy; Schmidt, Julie A.; Jacobs, Inarie; Tjønneland, Anne; Olsen, Anja; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena Andrea; Schulze, Matthias B.; Prada, Marcela; Masala, Giovanna; Agnoli, Claudia; Panico, Salvatore; Sacerdote, Carlotta; Jakszyn, Paula; Sánchez, María-José; Castilla, Jesús; Chirlaque, Maria-Dolores; Aizpurua Atxega, Amaia; Van Guelpen, Bethany; Heath, Alicia K.; Papier, Keren; Tong, Tammy Y. N.; Summers, Scott A.; Playdon, Mary; Cross, Amanda J.; Keski-Rahkonen, Pekka; Chajès, Véronique; Murphy, Neil; Gunter, Marc J. (eBioMedicine, 2024, 101: 105024, 2024-03)
      Background Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods In a case–control study ...

    • Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 European countries: A multinational cohort study 

      Murphy, Neil; Ward, Heather A.; Jenab, Mazda; Rothwell, Joseph A.; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Kvaskoff, Marina; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Aleksandrova, Krasimira; Weiderpass, Elisabete; Skeie, Guri; Benjaminsen Borch, Kristin; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Dahm, Christina C.; Jakszyn, Paula; Sánchez, Maria Jose; Gil , Leire; Huerta, José María; Barricarte, Aurelio; Quirós, José Ramón; Khaw, Kay-Tee; Wareham, Nick; Bradbury, Kathryn E.; Trichopoulou, Antonia; La Vecchia, Carlo; Karakatsani, Anna; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Fasanelli, Francesca; Panico, Salvatore; Bueno de Mesquita, H. Bas; Peeters, Petra H.; Gylling, Bjorn; Myte, Robin; Jirström, Karin; Berntsson, Jonna; Xue, Xiaonan; Riboli, Elio; Cross, Amanda J.; Gunter, Marc J. (Clinical Gastroenterology and Hepatology, 2019, 17(7): 1323-1331, 2019-06)
      Background & Aims Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent ...

    • Identifying metabolomic mediators of the physical activity and colorectal cancer relationship 

      Papadimitriou, Nikos; Kazmi, Nabila; Tsilidis, Konstantinos K.; Richmond, Rebecca C.; Lynch, Brigid M.; Bendinelli, Benedetta; Ricceri, Fulvio; Sánchez, Maria Jose; Trobajo-Sanmartín, Camino; Jakszyn, Paula; Simeon, Vittorio; Severi, Gianluca; Perduca, Vittorio; Truong, Therese; Ferrari, Pietro; Keski-Rahkonen, Pekka; Weiderpass, Elisabete; Eichelmann, Fabian; Schulze, Matthias B.; Katzke, Verena Andrea; Turzanski‑Fortner, Renée; Heath, Alicia K.; Aune, Dagfnn; Harewood, Rhea; Dahm, Christina C.; Llorente, Adrian; Gunter, Marc J.; Murphy, Neil; Lewis, Sarah Jayne (Cancer epidemiology, biomarkers and prevention, 2025, 34(4): 578-587, 2025-04)
      Background: Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer. However, the mediating role of the circulating metabolome in this ...

    • Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study 

      Jakszyn, Paula; Cayssials, Valerie; Buckland, Genevieve; Perez-Cornago, Aurora; Weiderpass, Elisabete; Boeing, Heiner; Bergmann, Manuela M.; Vulcan, Alexandra; Ohlsson, Bodil; Masala, Giovanna; Cross, Amanda J.; Riboli, Elio; Ricceri, Fulvio; Dahm, Christina C.; Nyvang, Dorthe; Katzke, Verena Andrea; Kühn, Tilman; Kyrø, Cecilie; Tjønneland, Anne; Ward, Heather A.; Tsilidis, Konstantinos K.; Skeie, Guri; Sieri, Sabina; Sánchez, María-José; Huerta, José María; Amiano, Pilar; Lasheras-Mayo, Maria Cristina; Ardanaz, Eva; Mahamat-Saleh, Yahya; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Panico, Salvatore; Peppa, Eleni; Trichopoulou, Antonia; Karakatsani, Anna; Tumino, Rosario; Vermeulen, Roel; Jenab, Mazda; Gunter, Marc J.; Agudo, Antonio (International Journal of Cancer, 2020, 147(4): 1027-1039, 2020-08)
      Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined ...

    • Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort 

      Rothwell, Joseph A.; Murphy, Neil; Bešević, Jelena; Kliemann, Nathalie; Jenab, Mazda; Ferrari, Pietro; Achaintre, David; Gicquiau, Audrey; Vozar, Beatrice; Scalbert, Augustin; Huybrechts, Inge; Freisling, Heinz; Prehn, Cornelia; Adamski, Jerzy; Cross, Amanda J.; Pala, Valeria Maria; Boutron-Ruault, Marie-Christine; Dahm, Christina C.; Overvad, Kim; Gram, Inger Torhild; Sandanger, Torkjel M.; Skeie, Guri; Jakszyn, Paula; Tsilidis, Kostas; Aleksandrova, Krasimira; Schulze, Matthias B.; Hughes, David J.; Van Guelpen, Bethany; Bodén, Stina; Sánchez, María-José; Schmidt, Julie A.; Katzke, Verena Andrea; Kühn, Tilman; Colorado-Yohar, Sandra; Tumino, Rosario; Bueno de Mesquita, H. Bas; Vineis, Paolo; Masala, Giovanna; Panico, Salvatore; Eriksen, Anne Kirstine; Tjønneland, Anne; Aune, Dagfnn; Weiderpass, Elisabete; Severi, Gianluca; Chajès, Véronique; Gunter, Marc J. (Clinical Gastroenterology and Hepatology, 2022, 20(5): e1061-e1082, 2022-05)
      Background & Aims Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of ...

    • Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP‑4) and risk of colorectal cancer 

      Nimptsch, Katharina; Aleksandrova, Krasimira; Thi Pham, Thu; Papadimitriou, Nikos; Janke, Jürgen; Christakoudi, Sofia; Heath, Alicia K.; Olsen, Anja; Tjønneland, Anne; Schulze, Matthias B.; Katzke, Verena Andrea; Kaaks, Rudolf; Van Guelpen, Bethany; Harbs, Justin; Palli, Domenico; Macciotta, Alessandra; Pasanisi, Fabrizio; Colorado-Yohar, Sandra; Guevara, Marcela; Amiano, Pilar; Grioni, Sara; Jakszyn, Paula; Figueiredo, Jane C.; Samadder, N. Jewel; Li, Christopher I.; Moreno, Victor; Potter, John D.; Schoen, Robert E.; Um, Caroline Y.; Weiderpass, Elisabete; Jenab, Mazda; Gunter, Marc J.; Pischon, Tobias (BMC Medicine, 2023, 21: 391, 2023-10)
      Background Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation ...

    • Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: Results from the EPIC cohort 

      Reichmann, Robin; Nimptsch, Katharina; Pischon, Tobias; Gunter, Marc J.; Jenab, Mazda; Eriksen, Anne Kirstine; Tjonneland, Anne; Janke, Jürgen; Katzke, Verena Andrea; Kaaks, Rudolf; Schulze, Matthias B.; Eichelmann, Fabian; Masala, Giovanna; Sieri, Sabina; Pasanisi, Fabrizio; Tumino, Rosario; Giraudo, Maria Teresa; Rothwell, Joseph A.; Severi, Gianluca; Jakszyn, Paula; Sanchez-Perez, Maria Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Guevara, Marcela; Van Guelpen, Bethany; Aglago, Elom K; Heath, Alicia K.; Smith-Byrne, Karl; Weiderpass, Elisabete; Aleksandrova, Krasimira (International Journal of Cancer, 2025, 156(5): 930-942, 2024-11)
      Experimental research has uncovered lipocalin 2 (LCN2) as a novel biomarker implicated in the modulation of intestinal inflammation, metabolic homeostasis, and colon carcinogenesis. However, evidence ...