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Browsing by Subject "Base recognition"

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    • Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1 

      Ondono, Raul; Lirio, Ángel; Carlos, Elvira; Álvarez-Marimon, Elena; Provenzano, Claudia; Cardinali, Beatrice; Pérez-Alonso, Manuel; Perálvarez-Marín, Alex; Borrell Bilbao, José Ignacio; Falcone, Germana; Estrada Tejedor, Roger (Computational and Structural Biotechnology Journal, 2020-11-28)
      Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity ...