Listando por materia "Miotonia atròfica"
Mostrando ítems 1-2 de 2
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Defined D-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease
(Scientific Reports, 2021-09-30)In Myotonic Dystrophy type 1 (DM1), a non-coding CTG repeats rare expansion disease; toxic double-stranded RNA hairpins sequester the RNA-binding proteins Muscleblind-like 1 and 2 (MBNL1 and 2) and ... -
Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1
(Computational and Structural Biotechnology Journal, 2020-11-28)Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity ...