Listando por materia "Enzims"
Mostrando ítems 1-6 de 6
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A practical guide to computational tools for engineering biocatalytic properties
(International Journal of Molecular Sciences 2025, 26(3), 980, 2025-02-01)The growing demand for efficient, selective, and stable enzymes has fueled advancements in computational enzyme engineering, a field that complements experimental methods to accelerate enzyme discovery. ... -
Control of Substrate Conformation by Hydrogen Bonding in a Retaining β-Endoglycosidase
(Chemistry - A European Journal 2023, 29(70), e202302555, 2023-12-14)Bacterial β-glycosidases are hydrolytic enzymes that depolymerize polysaccharides such as β-cellulose, β-glucans and β-xylans from different sources, offering diverse biomedical and industrial uses. It ... -
Evaluating the alterations of the estrogen-responsive genes in Cyprinodon variegatus larvae for biomonitoring the impacts of estrogenic endocrine disruptors (EEDs)
(Environmental Toxicology and Pharmacology 2023, 97, 104042, 2023-01)Currently, endocrine disruptors (EDs) can be found in all the environmental compartments. To understand the effects of estrogenic EDs (EEDs), adults of Cyprinodon variegatus have been classically used ... -
Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor
(Journal of Medicinal Chemistry, 2022, 65(8), 6070-6087, 2022-04-28)Targeting the kinases MNK1 and MNK2 has emerged as a valuable strategy in oncology. However, most of the advanced inhibitors are acting in an adenosine triphosphate (ATP)-competitive mode, precluding ... -
Structural-functional analysis reveals a specific domain organization in family GH20 hexosaminidases
(PLoS ONE. Vol.10, n.5 (2015), e0128075, 2015-05)Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates. The GH20 enzymes present diverse ... -
Structure-function features of a mycoplasma glycolipid synthase derived from structural data integration, molecular simulations, and mutational analysis
(PLoS One. Vol.8, n.12 (2013), e81990, 2013-12)Glycoglycerolipids are structural components of mycoplasma membranes with a fundamental role in membrane properties and stability. Their biosynthesis is mediated by glycosyltransferases (GT) that catalyze ...