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Browsing by Subject "L-sugars"

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    • Protein flexibility drives sugar rotation and high substrate promiscuity in a GDP-sugar 4-epimerase 

      Alvarez Quispe, Carlos Josue; Beerens, Koen; Thunnissen, Andy-Mark; Biarnés, Xevi; Planas, Antoni; Desmet, Tom (Research Network of Computational and Structural Biotechnology 2025, 27, 2375-2385, 2025)
      UDP-galactose 4-epimerases (Gal4Es) catalyze the inversion of the 4-hydroxyl configuration of a sugar moiety from an NDP-sugar through a three-step process: oxidation, rotation and reduction. Despite ...