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    • Mutated RAS-associating proteins and ERK activation in relapse/refractory diffuse large B cell lymphoma 

      Benoit, Alexandre; Bou Petit, Elisabeth; Chou, Hsiang; Lu, Melissa; Guilbert, Cynthia; Mingyi Luo, Vincent; Assouline, Sarit; Morin, Ryan D; Dmitrienko, Svetlana; Estrada Tejedor, Roger; Johnson, Nathalie A.; Mann, Koren K. (Scientific Reports 2022, 12, 779, 2022)
      Diffuse large B cell lymphoma (DLBCL) is successfully treated with combination immuno-chemotherapy, but relapse with resistant disease occurs in ~ 40% of patients. However, little is known regarding ...

    • Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor 

      Bou Petit, Elisabeth; Hümmer, Stefan; Alarcon, Helena; Slobodnyuk, Konstantin; Cano Galietero, Marta; Fuentes, Pedro; Guijarro, Pedro J.; Muñoz, María José; Suarez Cabrera, Leticia; Santamaria, Anna; Estrada Tejedor, Roger; Borrell Bilbao, José Ignacio; Ramón y Cajal, Santiago (Journal of Medicinal Chemistry, 2022, 65(8), 6070-6087, 2022-04-28)
      Targeting the kinases MNK1 and MNK2 has emerged as a valuable strategy in oncology. However, most of the advanced inhibitors are acting in an adenosine triphosphate (ATP)-competitive mode, precluding ...