Visualitzant per matèria "Synthetic cathinones"
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Behavioural and neurochemical effects after repeated administration of N-ethylpentylone (ephylone) in mice
(Journal of Neurochemistry, 2022, 160(2), 218-233, 2022)N-ethyl-pentylone (NEP), also known as ‘ephylone’ and N-ethylnorpentylone, has been identified as one of the most recent novel psychostimulants to emerge into the illicit drug market and it has been ... -
Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice
(Progress in Neuro-Psychopharmacology and Biological Psychiatry 2022, 117, 110562, 2022-07)N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into the illicit drug market. This drug has psychostimulant properties ... -
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
(Neuropharmacology, 2021-03-15)The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present ... -
Structure–Activity Relationship of N-Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral Effects in Mice
(ACS Chemical Neuroscience 2023, 14 (4), 2023-02-15)Synthetic cathinones are β-keto amphetamine derivatives whose appearance has increased dramatically in the past decades. N-Ethyl substituted cathinones have been proven to potently inhibit dopamine (DA) ... -
Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes
(Frontiers in Pharmacology 2021;12:749429, 2021-10-26)Several new synthetic cathinones, which mimic the effect of classical psychostimulants such as cocaine or MDMA, have appeared in the global illicit drug market in the last decades. In fact, the illicit ...