Visualitzant per matèria "Proteïnes"
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A practical guide to computational tools for engineering biocatalytic properties
(International Journal of Molecular Sciences 2025, 26(3), 980, 2025-02-01)The growing demand for efficient, selective, and stable enzymes has fueled advancements in computational enzyme engineering, a field that complements experimental methods to accelerate enzyme discovery. ... -
Binding of common organic UV-filters to the thyroid hormone transport protein transthyretin using in vitro and in silico studies: Potential implications in health.
(Environmental Research 2023, 217, 114836, 2023-01-15)Several anthropogenic contaminants have been identified as competing with the thyroid hormone thyroxine (T4) for binding to transport proteins as transthyretin (TTR). This binding can potentially create ... -
Different mechanisms that promote protein monoubiquitination
(Afinidad. Vol.72, n.570 (2015), p.95-100, 2015-04)Protein monoubiquitination is a post-translational modification that consists of the conjugation of a single ubiquitin molecule to a target protein residue. Monoubiquitination regulates protein activity ... -
Evaluating the alterations of the estrogen-responsive genes in Cyprinodon variegatus larvae for biomonitoring the impacts of estrogenic endocrine disruptors (EEDs)
(Environmental Toxicology and Pharmacology 2023, 97, 104042, 2023-01)Currently, endocrine disruptors (EDs) can be found in all the environmental compartments. To understand the effects of estrogenic EDs (EEDs), adults of Cyprinodon variegatus have been classically used ... -
Preparative scale production of recombinant human transthyretin for biophysical studies of protein-ligand and protein-protein interactions
(International Journal of Molecular Sciences. Vol.21, n.24 (2020), 9640, 2020-12)Human transthyretin (hTTR), a serum protein with a main role in transporting thyroid hormones and retinol through binding to the retinol-binding protein, is an amyloidogenic protein involved in familial ... -
Riboflavin-binding proteins for singlet oxygen production
(Photochemical & Photobiological Sciences 2022, 21, 1545–1555, 2022)miniSOG, developed as the first fully genetically encoded singlet oxygen photosensitiser, has found various applications in cell imaging and functional studies. Yet, miniSOG has suboptimal properties, ... -
Structural-functional analysis reveals a specific domain organization in family GH20 hexosaminidases
(PLoS ONE. Vol.10, n.5 (2015), e0128075, 2015-05)Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates. The GH20 enzymes present diverse ... -
The Masking Game: Design of Activatable Antibodies and Mimetics for Selective Therapeutics and Cell Control
(ACS Central Science, 2021-04-26)The high selectivity and affinity of antibody binding havemade antibodies all-pervasive tools in therapy, diagnosis, and basic science.A plethora of chemogenetic approaches has been devised to makeantibodies ... -
Versatile Supramolecular Complex for Targeted Antimicrobial Photodynamic Inactivation
(Bioconjugate Chemistry 2022, 33(4), 666–676, 2022-04-20)We report the development of a supramolecular structure endowed with photosensitizing properties and targeting capability for antimicrobial photodynamic inactivation. Our synthetic strategy uses the ...