• An antibody-photosensitiser bioconjugate overcomes trastuzumab resistance in HER2-positive breast cancer 

      Jordà Redondo, Mireia; Piqueras, Ana; Castillo, Ana; Fernandez, Pedro Luis; Bresolí Obach, Roger; Blay, Lidia; Julian Ibañez, Joan Francesc; Nonell, Santi (European Journal of Medicinal Chemistry 2025, 290, 2025-06-05)
      HER2-positive breast cancer, characterized by the overexpression of HER2 receptors, often develops resistance to trastuzumab, limiting its therapeutic efficacy. In this study, we explore the use of ...
    • NanoSOSG: A Nanostructured Fluorescent Probe for the Detection of Intracellular Singlet Oxygen 

      Ruiz González, Rubén; Bresolí-Obach, Roger; Gulias, Oscar; Agut, Montserrat; Savoie, Huguette; Boyle, Ross W.; Nonell, Santi; Giuntini, Francesca (Angewandte Chemie International Edition 2017, 56 (11), 2017-03-06)
      A biocompatible fluorescent nanoprobe for singlet oxygen (1O2) detection in biological systems was designed, synthesized, and characterized, that circumvents many of the limitations of the molecular ...
    • Una visión moderna sobre la desactivación de cetonas aromáticas por beta-fenilos 

      Bresolí Obach, Roger; Nonell, Santi (Afinidad. Vol.73, n.574 (2016), p.90-95, 2016-04)
      La desactivación por beta fenilos (en inglés, Beta Phenyl Quenching o BPQ) es una reacción que se produce a partir del estado triplete de cetonas aromáticas con un grupo fenilo en posición beta. Esta ...