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    • Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates 

      Rovira, Anna; Ortega Forte, Enrique; Hally, Cormac; Jordà Redondo, Mireia; Abad-Montero, Diego; Vigueras, Gloria; Martínez, Jesús I.; Bosch, Manel; Nonell, Santi; Ruiz, José; Marchán, Vicente (Journal of Medicinal Chemistry 2023, 66 (12), 2023-06-22)
      Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under ...

    • Innovative light sources for phototherapy 

      Romano, Giovanni; Insero, Giacomo; Nonell, Santi; Fusi, Franco (Biomolecular Concepts 2022, 13(1), 256-271, 2022)
      The use of light for therapeutic purposes dates back to ancient Egypt, where the sun itself was an innovative source, probably used for the first time to heal skin diseases. Since then, technical ...

    • On the mechanism of Candida tropicalis biofilm reduction by the combined action of naturally-occurring anthraquinones and blue light 

      Nonell, Santi; Bresolí Obach, Roger; Agut, Montserrat; Marioni, Juliana; Comini, Laura R.; Cabrera, José L.; Paraje, María G.; Núñez Montoya, Susana C. (PLoS ONE. Vol.12, n.7 (2017), e0181517, 2017-07)
      The photoprocesses involved in the photo-induced Candida tropicalis biofilm reduction by two natural anthraquinones (AQs), rubiadin (1) and rubiadin-1-methyl ether (2), were examined. Production of ...

    • Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors 

      Abad-Montero, Diego; Gandioso, Albert; Izquierdo García, Eduardo; Chumillas, Sergi; Rovira, Anna; Bosch, Manel; Jordà-Redondo, Mireia; Castaño, Davor; Bonelli, Joaquín; Novikov, Valentin; Deyà, Alba; Hernández, José Luis; Galino, Jorge; Alberto, Marta Erminia; Francés-Monerris, Antonio; Nonell, Santi; Gasser, Gilles; Marchán, Vicente (Journal of the American Chemical Society 2025, 147 (9), 7360–7376, 2025-03-05)
      Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance to conventional therapies, leading to poor patient outcomes. This challenges the ...