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    • Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates 

      Rovira, Anna; Ortega Forte, Enrique; Hally, Cormac; Jordà Redondo, Mireia; Abad-Montero, Diego; Vigueras, Gloria; Martínez, Jesús I.; Bosch, Manel; Nonell, Santi; Ruiz, José; Marchán, Vicente (Journal of Medicinal Chemistry 2023, 66 (12), 2023-06-22)
      Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under ...

    • Mitochondria-Targeted COUPY Photocages: Synthesis and Visible-Light Photoactivation in Living Cells 

      López Corrales, Marta; Rovira, Anna; Gandioso, Albert; Nonell, Santi; Bosch, Manel; Marchán, Vicente (The Journal of Organic Chemistry 2023, 88, 7128-7140, 2023-06-02)
      Releasing bioactive molecules in specific subcellular locations from the corresponding caged precursors offers great potential in photopharmacology, especially when using biologically compatible visible ...

    • Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors 

      Abad-Montero, Diego; Gandioso, Albert; Izquierdo García, Eduardo; Chumillas, Sergi; Rovira, Anna; Bosch, Manel; Jordà-Redondo, Mireia; Castaño, Davor; Bonelli, Joaquín; Novikov, Valentin; Deyà, Alba; Hernández, José Luis; Galino, Jorge; Alberto, Marta Erminia; Francés-Monerris, Antonio; Nonell, Santi; Gasser, Gilles; Marchán, Vicente (Journal of the American Chemical Society 2025, 147 (9), 7360–7376, 2025-03-05)
      Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance to conventional therapies, leading to poor patient outcomes. This challenges the ...