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Metabolic flux balance analysis during lactate and glucose concomitant consumption in HEK293 cell cultures

Martínez-Monge, Iván; Albiol, Joan; Lecina i Veciana, Martí; Liste Calleja, Leticia; Miret, Joan; Solà, Carles; Cairó, Jordi Joan (Biotechnology and Bioengineering, 2018-10-26)

At early stages of the exponential growth phase in HEK293 cell cultures, the tricarboxylic acid cycle is unable to process all the amount of NADH generated in the glycolysis pathway, being lactate the ...