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Dedifferentiated human articular chondrocytes redifferentiate to a cartilage-like tissue phenotype in a poly(ε-caprolactone)/self-assembling peptide composite scaffold

Semino, Carlos; Abella, Jordi; Recha Sancho, Lourdes Georgina; Moutos, Franklin T.; Guilak, Farshid (Materials. Vol.9, n.6 (2016), 472, 2016-06)

Adult articular cartilage has a limited capacity for growth and regeneration and, with injury, new cellular or biomaterial-based therapeutic platforms are required to promote repair. Tissue engineering ...
Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model

Semino, Carlos; Sennett, M. L.; Friedman, J. M.; Ashley, B. S.; Stoeckl, B. D.; Patel, J. M.; Alini, M.; Cucchiarini, M.; Eglin, D.; Madry, H.; Mata, A.; Stoddart, M. J.; Johnstone, B.; Moutos, Franklin T.; Estes, B. T.; Guilak, Farshid; Mauck, R. L.; Dodge, G. R. (European Cells & Materials Journal, 2021-01-07)

The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics. Chondral defects may arise from a variety of joint pathologies and left untreated, will likely ...