Listando por autor/a "Llamusi, Beatriz"
Mostrando ítems 1-2 de 2
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Defined D-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease
Rapisarda, Anna; Bargiela, Ariadna; Llamusi, Beatriz; Pont, Isabel; Estrada Tejedor, Roger; Garcia-España, Enrique; Artero, Ruben; Perez-Alonso, Manuel (Scientific Reports, 2021-09-30)In Myotonic Dystrophy type 1 (DM1), a non-coding CTG repeats rare expansion disease; toxic double-stranded RNA hairpins sequester the RNA-binding proteins Muscleblind-like 1 and 2 (MBNL1 and 2) and ... -
In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models
Estrada Tejedor, Roger; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; González, Àlex L.; Konieczn, Piotr; Llamusi, Beatriz; Delgado-Pinar, Estefanía; García-España, Enrique; Pérez-Alonso, Manuel; Artero, Rubén (PLoS ONE. Vol.12, n.6 (2017), e0178931, 2017-06)Myotonic dystrophy type 1 (DM1) is a rare multisystemic disorder associated with an expansion of CUG repeats in mutant DMPK (dystrophia myotonica protein kinase) transcripts; the main effect of these ...